BAIT
CLB5
B-type cyclin CLB5, L000000353, YPR120C
B-type cyclin involved in DNA replication during S phase; activates Cdc28p to promote initiation of DNA synthesis; functions in formation of mitotic spindles along with Clb3p and Clb4p; most abundant during late G1 phase; CLB5 has a paralog, CLB6, that arose from the whole genome duplication
GO Process (7)
GO Function (1)
GO Component (1)
Gene Ontology Biological Process
- G1/S transition of mitotic cell cycle [IEP, IMP]
- G2/M transition of mitotic cell cycle [IEP, IMP]
- positive regulation of DNA replication [IMP]
- positive regulation of spindle pole body separation [IGI]
- premeiotic DNA replication [IGI, IMP]
- regulation of cyclin-dependent protein serine/threonine kinase activity [IDA]
- spindle assembly [IGI, IMP]
Gene Ontology Molecular Function
Saccharomyces cerevisiae (S288c)
PREY
ARG82
ARGR3, IPK2, inositol polyphosphate multikinase, ARGRIII, L000002727, YDR173C
Inositol polyphosphate multikinase (IPMK); sequentially phosphorylates Ins(1,4,5)P3 to form Ins(1,3,4,5,6)P5; also has diphosphoinositol polyphosphate synthase activity; regulates arginine-, phosphate-, and nitrogen-responsive genes
GO Process (6)
GO Function (7)
GO Component (1)
Gene Ontology Biological Process
- inositol phosphate biosynthetic process [IDA]
- negative regulation of transcription from RNA polymerase II promoter [IMP]
- phosphatidylinositol phosphorylation [IDA]
- positive regulation of transcription from RNA polymerase II promoter [IMP]
- protein stabilization [IMP]
- regulation of arginine metabolic process [IMP]
Gene Ontology Molecular Function- inositol tetrakisphosphate 3-kinase activity [IDA]
- inositol tetrakisphosphate 6-kinase activity [IDA]
- inositol-1,3,4,5,6-pentakisphosphate kinase activity [IDA]
- inositol-1,4,5-trisphosphate 3-kinase activity [IMP]
- inositol-1,4,5-trisphosphate 6-kinase activity [IDA]
- phosphatidylinositol 3-kinase activity [IDA]
- protein binding, bridging [IMP, IPI]
- inositol tetrakisphosphate 3-kinase activity [IDA]
- inositol tetrakisphosphate 6-kinase activity [IDA]
- inositol-1,3,4,5,6-pentakisphosphate kinase activity [IDA]
- inositol-1,4,5-trisphosphate 3-kinase activity [IMP]
- inositol-1,4,5-trisphosphate 6-kinase activity [IDA]
- phosphatidylinositol 3-kinase activity [IDA]
- protein binding, bridging [IMP, IPI]
Saccharomyces cerevisiae (S288c)
Negative Genetic
Mutations/deletions in separate genes, each of which alone causes a minimal phenotype, but when combined in the same cell results in a more severe fitness defect or lethality under a given condition. This term is reserved for high or low throughput studies with scores.
Publication
Rewiring of genetic networks in response to DNA damage.
Although cellular behaviors are dynamic, the networks that govern these behaviors have been mapped primarily as static snapshots. Using an approach called differential epistasis mapping, we have discovered widespread changes in genetic interaction among yeast kinases, phosphatases, and transcription factors as the cell responds to DNA damage. Differential interactions uncover many gene functions that go undetected in static conditions. They ... [more]
Science Dec. 03, 2010; 330(6009);1385-9 [Pubmed: 21127252]
Quantitative Score
- -2.801178 [SGA Score]
Throughput
- High Throughput
Ontology Terms
- phenotype: colony size (APO:0000063)
- phenotype: resistance to chemicals (APO:0000087)
Additional Notes
- An Epistatic MiniArray Profile (E-MAP) approach was used to quantitatively score genetic interactions based on fitness defects estimated from the colony size of double versus single mutants in MMS-treated conditions. Genetic interactions were considered significant if they had an S score >=2.0 for positive interactions (epistatic or suppressor interactions) and S score <=2.5 for negative interactions (synthetic sick/lethal interactions).
Curated By
- BioGRID