PHO80
Gene Ontology Biological Process
- cellular metal ion homeostasis [IMP]
- negative regulation of calcium-mediated signaling [IGI]
- negative regulation of macroautophagy [IMP]
- negative regulation of phosphate metabolic process [IGI]
- negative regulation of transcription from RNA polymerase II promoter [IGI]
- regulation of cyclin-dependent protein serine/threonine kinase activity [IDA]
- regulation of protein localization [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
BCK1
Gene Ontology Biological Process
- endoplasmic reticulum unfolded protein response [IMP]
- establishment of cell polarity [IMP]
- intracellular signal transduction [IMP]
- peroxisome degradation [IMP]
- protein phosphorylation [IDA, TAS]
- regulation of fungal-type cell wall organization [IGI, IMP]
- response to acidic pH [IMP]
- response to nutrient [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Negative Genetic
Mutations/deletions in separate genes, each of which alone causes a minimal phenotype, but when combined in the same cell results in a more severe fitness defect or lethality under a given condition. This term is reserved for high or low throughput studies with scores.
Publication
Rewiring of genetic networks in response to DNA damage.
Although cellular behaviors are dynamic, the networks that govern these behaviors have been mapped primarily as static snapshots. Using an approach called differential epistasis mapping, we have discovered widespread changes in genetic interaction among yeast kinases, phosphatases, and transcription factors as the cell responds to DNA damage. Differential interactions uncover many gene functions that go undetected in static conditions. They ... [more]
Quantitative Score
- -4.117273 [SGA Score]
Throughput
- High Throughput
Ontology Terms
- colony size (APO:0000063)
- resistance to chemicals (APO:0000087)
Additional Notes
- An Epistatic MiniArray Profile (E-MAP) approach was used to quantitatively score genetic interactions based on fitness defects estimated from the colony size of double versus single mutants in MMS-treated conditions. Genetic interactions were considered significant if they had an S score >=2.0 for positive interactions (epistatic or suppressor interactions) and S score <=2.5 for negative interactions (synthetic sick/lethal interactions).
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| BCK1 PHO80 | Dosage Growth Defect Dosage Growth Defect A genetic interaction is inferred when over expression or increased dosage of one gene causes a growth defect in a strain that is mutated or deleted for another gene. | High | -0.235 | BioGRID | 908637 | |
| BCK1 PHO80 | Negative Genetic Negative Genetic Mutations/deletions in separate genes, each of which alone causes a minimal phenotype, but when combined in the same cell results in a more severe fitness defect or lethality under a given condition. This term is reserved for high or low throughput studies with scores. | High | -0.1415 | BioGRID | 2135998 |
Curated By
- BioGRID