APOB
Gene Ontology Biological Process
- blood coagulation [TAS]
- cholesterol homeostasis [IMP]
- cholesterol metabolic process [IMP]
- cholesterol transport [IMP]
- leukocyte migration [TAS]
- lipoprotein metabolic process [TAS]
- low-density lipoprotein particle clearance [IMP]
- low-density lipoprotein particle remodeling [IMP]
- phototransduction, visible light [TAS]
- positive regulation of cholesterol storage [IDA]
- positive regulation of lipid storage [IDA]
- positive regulation of macrophage derived foam cell differentiation [IDA]
- receptor-mediated endocytosis [TAS]
- response to virus [IEP]
- retinoid metabolic process [TAS]
- small molecule metabolic process [TAS]
- very-low-density lipoprotein particle assembly [IC]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- Golgi apparatus [IDA]
- actin cytoskeleton [IDA]
- chylomicron [IDA]
- chylomicron remnant [TAS]
- clathrin-coated endocytic vesicle membrane [TAS]
- cytoplasm [IDA]
- cytosol [TAS]
- early endosome [TAS]
- endocytic vesicle lumen [TAS]
- endoplasmic reticulum lumen [TAS]
- endoplasmic reticulum membrane [TAS]
- endosome lumen [TAS]
- endosome membrane [TAS]
- extracellular region [TAS]
- extracellular space [ISS]
- extracellular vesicular exosome [IDA]
- intermediate-density lipoprotein particle [IDA]
- intracellular membrane-bounded organelle [TAS]
- low-density lipoprotein particle [IDA]
- mature chylomicron [IDA]
- plasma membrane [IDA, TAS]
- very-low-density lipoprotein particle [IDA]
CANX
Gene Ontology Biological Process
- antigen processing and presentation of exogenous peptide antigen via MHC class II [TAS]
- antigen processing and presentation of peptide antigen via MHC class I [TAS]
- cellular protein metabolic process [TAS]
- clathrin-mediated endocytosis [ISS]
- post-translational protein modification [TAS]
- protein N-linked glycosylation via asparagine [TAS]
- protein folding [TAS]
- protein secretion [TAS]
- synaptic vesicle endocytosis [ISS]
Gene Ontology Molecular Function
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
Proteasome-mediated degradation of apolipoprotein B targets both nascent peptides cotranslationally before translocation and full-length apolipoprotein B after translocation into the endoplasmic reticulum.
A major portion of newly synthesized apolipoprotein B (apoB) is degraded intracellularly. This degradation has been demonstrated to be mediated largely by the ubiquitin-proteasome pathway. We examined whether nascent apoB polypeptides or full-length apoB is selectively retrotranslocated from the endoplasmic reticulum into the cytosol for degradation. Herein, we found that full-length apoB as well as partial-length apoB peptides are ubiquitinated ... [more]
Throughput
- Low Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| CANX APOB | Affinity Capture-Western Affinity Capture-Western An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins. | Low | - | BioGRID | - |
Curated By
- BioGRID