BAIT

CLB1

SCB1, B-type cyclin CLB1, L000000349, YGR108W
B-type cyclin involved in cell cycle progression; activates Cdc28p to promote the transition from G2 to M phase; accumulates during G2 and M, then targeted via a destruction box motif for ubiquitin-mediated degradation by the proteasome; CLB1 has a paralog, CLB2, that arose from the whole genome duplication
Kinome Project (Sc)
Saccharomyces cerevisiae (S288c)
PREY

SWE1

WEE1, tyrosine protein kinase SWE1, L000002248, YJL187C
Protein kinase that regulates the G2/M transition; regulates the G2/M transition by inhibition of Cdc28p kinase activity; localizes to the nucleus and to the daughter side of the mother-bud neck; phosphorylates conserved tyrosine residue in N-terminus of Hsp90 in cell-cycle associated manner, thus modulating the ability of Hsp90 to chaperone a selected clientele; homolog of S. pombe Wee1p; potential Cdc28p substrate
Kinome Project (Sc)
Saccharomyces cerevisiae (S288c)

Phenotypic Enhancement

A genetic interaction is inferred when mutation or overexpression of one gene results in enhancement of any phenotype (other than lethality/growth defect) associated with mutation or over expression of another gene.

Publication

The Budding Yeast Polo-Like Kinase Cdc5 Regulates the Ndt80 Branch of the Meiotic Recombination Checkpoint Pathway.

Acosta I, Ontoso D, San-Segundo PA

Defects in chromosome synapsis and/or meiotic recombination activate a surveillance mechanism that blocks meiotic cell cycle progression to prevent anomalous chromosome segregation and formation of aberrant gametes. In the budding yeast zip1 mutant, lacking a synaptonemal complex component, the meiotic recombination checkpoint is triggered resulting in extremely delayed meiotic progression. We report that overproduction of the polo-like kinase Cdc5 partially ... [more]

Unknown Jul. 27, 2011; 0(0); [Pubmed: 21795394]

Throughput

  • Low Throughput

Ontology Terms

  • meiosis (APO:0000039)

Additional Notes

  • Overexpression of CLB1 in combination with deletion of Swe1 cooperatively overcome the block in meiosis seen in a Zip1 mutant

Related interactions

InteractionExperimental Evidence CodeDatasetThroughputScoreCurated ByNotes
SWE1 CLB1
Dosage Growth Defect
Dosage Growth Defect

A genetic interaction is inferred when over expression or increased dosage of one gene causes a growth defect in a strain that is mutated or deleted for another gene.

Low-BioGRID
1115505

Curated By

  • BioGRID