BAIT

LEM2

heh1, SPAC18G6.10
LEM domain protein Heh1/Lem2
Schizosaccharomyces pombe (972h)
PREY

MAN1

heh2, mug61, SPAC14C4.05c
LEM domain protein Man1, Sad1 interacting factor (predicted)
Schizosaccharomyces pombe (972h)

Phenotypic Enhancement

A genetic interaction is inferred when mutation or overexpression of one gene results in enhancement of any phenotype (other than lethality/growth defect) associated with mutation or over expression of another gene.

Publication

Inner nuclear membrane protein Ima1 is dispensable for intranuclear positioning of centromeres.

Hiraoka Y, Maekawa H, Asakawa H, Chikashige Y, Kojidani T, Osakada H, Matsuda A, Haraguchi T

Inner nuclear membrane (INM) proteins play a role in spatial organization of chromosomes within the nucleus. In the fission yeast Schizosaccharomyces pombe, Sad1, an INM protein of the conserved SUN-domain family, plays an active role in moving chromosomes along the nuclear membranes during meiotic prophase. Ima1 is another conserved INM protein recently identified. A previous study claimed that Ima1 is ... [more]

Unknown Sep. 01, 2011; 0(0); [Pubmed: 21880100]

Throughput

  • Low Throughput

Ontology Terms

  • phenotype: nuclear morphology (APO:0000057)
  • phenotype: size of nucleus (APO:0000119)

Related interactions

InteractionExperimental Evidence CodeDatasetThroughputScoreCurated ByNotes
LEM2 MAN1
Phenotypic Suppression
Phenotypic Suppression

A genetic interaction is inferred when mutation or over expression of one gene results in suppression of any phenotype (other than lethality/growth defect) associated with mutation or over expression of another gene.

Low-BioGRID
2332746
LEM2 MAN1
Synthetic Growth Defect
Synthetic Growth Defect

A genetic interaction is inferred when mutations in separate genes, each of which alone causes a minimal phenotype, result in a significant growth defect under a given condition when combined in the same cell.

Low-BioGRID
559756
LEM2 MAN1
Synthetic Lethality
Synthetic Lethality

A genetic interaction is inferred when mutations or deletions in separate genes, each of which alone causes a minimal phenotype, result in lethality when combined in the same cell under a given condition.

Low-BioGRID
559758
MAN1 LEM2
Two-hybrid
Two-hybrid

Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.

High-BioGRID
-

Curated By

  • BioGRID