CDK5R1
Gene Ontology Biological Process
- G-protein coupled acetylcholine receptor signaling pathway [ISS]
- axon guidance [ISS, TAS]
- axonal fasciculation [ISS]
- brain development [ISS, NAS]
- cell proliferation [TAS]
- ephrin receptor signaling pathway [ISS]
- ionotropic glutamate receptor signaling pathway [ISS]
- negative regulation of transcription, DNA-templated [IMP]
- neuron cell-cell adhesion [ISS]
- neuron differentiation [ISS]
- neuron migration [ISS]
- neuron projection development [ISS]
- peptidyl-serine phosphorylation [IDA]
- peptidyl-threonine phosphorylation [IDA]
- positive regulation of neuron apoptotic process [ISS]
- positive regulation of protein serine/threonine kinase activity [IDA, ISS]
- regulation of cyclin-dependent protein serine/threonine kinase activity [TAS]
- regulation of dendritic spine morphogenesis [ISS]
- regulation of neuron differentiation [NAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- axon [ISS]
- contractile fiber [ISS]
- cytoplasm [ISS]
- cytosol [TAS]
- dendrite [ISS]
- dendritic spine [ISS]
- growth cone [ISS]
- intracellular membrane-bounded organelle [IDA]
- membrane [ISS]
- neuromuscular junction [ISS]
- neuronal cell body [ISS]
- nucleoplasm [IDA]
- nucleus [ISS]
- perinuclear region of cytoplasm [IDA]
- postsynaptic density [ISS]
HSP90AA1
Gene Ontology Biological Process
- ATP catabolic process [IDA]
- Fc-gamma receptor signaling pathway involved in phagocytosis [TAS]
- G2/M transition of mitotic cell cycle [TAS]
- axon guidance [TAS]
- chaperone-mediated protein complex assembly [IDA]
- innate immune response [TAS]
- mitochondrial transport [TAS]
- mitotic cell cycle [TAS]
- nitric oxide metabolic process [TAS]
- positive regulation of nitric oxide biosynthetic process [ISS]
- protein import into mitochondrial outer membrane [IDA]
- protein refolding [TAS]
- regulation of nitric-oxide synthase activity [TAS]
- response to unfolded protein [NAS]
- signal transduction [NAS]
- small molecule metabolic process [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Reconstituted Complex
An interaction is inferred between proteins in vitro. This can include proteins in recombinant form or proteins isolated directly from cells with recombinant or purified bait. For example, GST pull-down assays where a GST-tagged protein is first isolated and then used to fish interactors from cell lysates are considered reconstituted complexes (e.g. PUBMED: 14657240, Fig. 4A or PUBMED: 14761940, Fig. 5). This can also include gel-shifts, surface plasmon resonance, isothermal titration calorimetry (ITC) and bio-layer interferometry (BLI) experiments. The bait-hit directionality may not be clear for 2 interacting proteins. In these cases the directionality is up to the discretion of the curator.
Publication
CHIP participates in protein triage decisions by preferentially ubiquitinating Hsp70-bound substrates.
The E3 ubiquitin ligase CHIP (C-terminus of Hsc70-interacting protein) is believed to be a central player in the cellular triage decision, as it links the molecular chaperones Hsp70/Hsc70 and Hsp90 to the ubiquitin proteasomal degradation pathway. To better understand the decision process, we determined the affinity of CHIP for Hsp70 and Hsp90 using isothermal titration calorimetry. We analyzed the influence ... [more]
Throughput
- Low Throughput
Curated By
- BioGRID