BAIT

CBK1

serine/threonine protein kinase CBK1, L000004609, YNL161W
Serine/threonine protein kinase of the the RAM signaling network; Ndr/LATS family member; binds regulatory subunit Mob2p; involved in regulation of cellular morphogenesis, polarized growth, and septum destruction; phosphorylation by Cbk1p regulates localization and activity of Ace2p transcription factor and Ssd1p translational repressor; Cbk1p activity is regulated by both phosphorylation and specific localization; relocalizes to cytoplasm upon DNA replication stress
Kinome Project (Sc)
Saccharomyces cerevisiae (S288c)
PREY

BCK2

CTR7, L000000163, YER167W
Serine/threonine-rich protein involved in PKC1 signaling pathway; protein kinase C (PKC1) signaling pathway controls cell integrity; overproduction suppresses pkc1 mutations
Kinome Project (Sc)
GO Process (3)
GO Function (0)
GO Component (2)

Gene Ontology Biological Process

Gene Ontology Cellular Component

Saccharomyces cerevisiae (S288c)

Dosage Rescue

A genetic interaction is inferred when over expression or increased dosage of one gene rescues the lethality or growth defect of a strain that is mutated or deleted for another gene.

Publication

Cbk1 kinase and Bck2 control MAP kinase activation and inactivation during heat shock.

Kuravi VK, Kurischko C, Puri M, Luca FC

Saccharomyces cerevisiae Cbk1 kinase is a LATS/NDR tumor suppressor orthologue and component of the RAM signaling network. Cbk1 was previously implicated in regulating polarized morphogenesis, gene expression and cell integrity. Here, we establish that Cbk1 is critical for heat shock and cell wall stress signaling via Bck2, a protein associated with the Pkc1-Mpk1 cell integrity pathway. We demonstrate that cbk1 ... [more]

Unknown Oct. 26, 2011; 0(0); [Pubmed: 22031291]

Throughput

  • Low Throughput

Ontology Terms

  • heat sensitivity (APO:0000147)
  • vegetative growth (APO:0000106)

Additional Notes

  • Overexpression of Bck2 or Rph1 partially rescues the temperature sensitivity of Cbk1

Curated By

  • BioGRID