BAIT
SEC2
guanine nucleotide exchange factor SEC2, L000001828, YNL272C
Guanyl-nucleotide exchange factor for the small G-protein Sec4p; essential for post-Golgi vesicle transport and for autophagy; associates with the exocyst, via exocyst subunit Sec15p, on secretory vesicles
GO Process (2)
GO Function (2)
GO Component (5)
Gene Ontology Biological Process
- autophagy [IGI, IMP]
- exocytosis [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Saccharomyces cerevisiae (S288c)
PREY
CDC55
TMR4, protein phosphatase 2A regulatory subunit CDC55, L000000282, S000029602, L000003191, YGL190C
Non-essential regulatory subunit B of protein phosphatase 2A (PP2A); localization to cytoplasm requires Zds1p and Zds2p and promotes mitotic entry; localization to nucleus prevents mitotic exit; required for correct nuclear division and chromosome segregation in meiosis; maintains nucleolar sequestration of Cdc14p during early meiosis; limits formation of PP2A-Rts1p holocomplexes to ensure timely dissolution of sister chromosome cohesion; homolog of mammalian B55
GO Process (7)
GO Function (1)
GO Component (6)
Gene Ontology Biological Process
- cytokinesis after mitosis checkpoint [IGI]
- negative regulation of exit from mitosis [IMP]
- positive regulation of G2/M transition of mitotic cell cycle [IMP]
- positive regulation of protein localization to nucleus [IMP]
- positive regulation of transcription by transcription factor localization [IMP]
- protein dephosphorylation [IDA, IMP]
- regulation of mitotic cell cycle spindle assembly checkpoint [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Saccharomyces cerevisiae (S288c)
Synthetic Lethality
A genetic interaction is inferred when mutations or deletions in separate genes, each of which alone causes a minimal phenotype, result in lethality when combined in the same cell under a given condition.
Publication
Phosphorylation provides a negative mode of regulation for the yeast Rab GTPase Sec4p.
The Rab family of Ras-related GTPases are part of a complex signaling circuitry in eukaryotic cells, yet we understand little about the mechanisms that underlie Rab protein participation in such signal transduction networks, or how these networks are integrated at the physiological level. Reversible protein phosphorylation is widely used by cells as a signaling mechanism. Several phospho-Rabs have been identified, ... [more]
PLoS ONE Sep. 21, 2011; 6(9);e24332 [Pubmed: 21931684]
Throughput
- Low Throughput
Ontology Terms
- inviable (APO:0000112)
Additional Notes
- sec2-59
Curated By
- BioGRID