AURKA
Gene Ontology Biological Process
- G2/M transition of mitotic cell cycle [TAS]
- anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process [TAS]
- mitotic cell cycle [TAS]
- mitotic nuclear division [TAS]
- mitotic spindle organization [IBA]
- negative regulation of protein binding [IDA]
- positive regulation of mitosis [TAS]
- protein autophosphorylation [TAS]
- protein phosphorylation [IDA]
- regulation of centrosome cycle [TAS]
- regulation of cytokinesis [IBA]
- regulation of protein stability [IMP]
- spindle stabilization [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- centrosome [IDA, TAS]
- chromosome passenger complex [IBA]
- condensed nuclear chromosome, centromeric region [IBA]
- cytosol [TAS]
- microtubule cytoskeleton [IDA]
- midbody [TAS]
- nucleus [IDA]
- perinuclear region of cytoplasm [IDA]
- spindle [TAS]
- spindle microtubule [IDA]
- spindle midzone [IBA]
- spindle pole centrosome [IDA]
AURKA
Gene Ontology Biological Process
- G2/M transition of mitotic cell cycle [TAS]
- anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process [TAS]
- mitotic cell cycle [TAS]
- mitotic nuclear division [TAS]
- mitotic spindle organization [IBA]
- negative regulation of protein binding [IDA]
- positive regulation of mitosis [TAS]
- protein autophosphorylation [TAS]
- protein phosphorylation [IDA]
- regulation of centrosome cycle [TAS]
- regulation of cytokinesis [IBA]
- regulation of protein stability [IMP]
- spindle stabilization [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- centrosome [IDA, TAS]
- chromosome passenger complex [IBA]
- condensed nuclear chromosome, centromeric region [IBA]
- cytosol [TAS]
- microtubule cytoskeleton [IDA]
- midbody [TAS]
- nucleus [IDA]
- perinuclear region of cytoplasm [IDA]
- spindle [TAS]
- spindle microtubule [IDA]
- spindle midzone [IBA]
- spindle pole centrosome [IDA]
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Systematic analysis of human protein complexes identifies chromosome segregation proteins.
Chromosome segregation and cell division are essential, highly ordered processes that depend on numerous protein complexes. Results from recent RNA interference screens indicate that the identity and composition of these protein complexes is incompletely understood. Using gene tagging on bacterial artificial chromosomes, protein localization, and tandem-affinity purification-mass spectrometry, the MitoCheck consortium has analyzed about 100 human protein complexes, many of ... [more]
Throughput
- High Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| AURKA AURKA | Biochemical Activity Biochemical Activity An interaction is inferred from the biochemical effect of one protein upon another, for example, GTP-GDP exchange activity or phosphorylation of a substrate by a kinase. The bait protein executes the activity on the substrate hit protein. A Modification value is recorded for interactions of this type with the possible values Phosphorylation, Ubiquitination, Sumoylation, Dephosphorylation, Methylation, Prenylation, Acetylation, Deubiquitination, Proteolytic Processing, Glucosylation, Nedd(Rub1)ylation, Deacetylation, No Modification, Demethylation. | Low | - | BioGRID | 3304030 | |
| AURKA AURKA | Biochemical Activity Biochemical Activity An interaction is inferred from the biochemical effect of one protein upon another, for example, GTP-GDP exchange activity or phosphorylation of a substrate by a kinase. The bait protein executes the activity on the substrate hit protein. A Modification value is recorded for interactions of this type with the possible values Phosphorylation, Ubiquitination, Sumoylation, Dephosphorylation, Methylation, Prenylation, Acetylation, Deubiquitination, Proteolytic Processing, Glucosylation, Nedd(Rub1)ylation, Deacetylation, No Modification, Demethylation. | Low | - | BioGRID | 838634 | |
| AURKA AURKA | Biochemical Activity Biochemical Activity An interaction is inferred from the biochemical effect of one protein upon another, for example, GTP-GDP exchange activity or phosphorylation of a substrate by a kinase. The bait protein executes the activity on the substrate hit protein. A Modification value is recorded for interactions of this type with the possible values Phosphorylation, Ubiquitination, Sumoylation, Dephosphorylation, Methylation, Prenylation, Acetylation, Deubiquitination, Proteolytic Processing, Glucosylation, Nedd(Rub1)ylation, Deacetylation, No Modification, Demethylation. | Low | - | BioGRID | 2600227 | |
| AURKA AURKA | Positive Genetic Positive Genetic Mutations/deletions in separate genes, each of which alone causes a minimal phenotype, but when combined in the same cell results in a less severe fitness defect than expected under a given condition. This term is reserved for high or low throughput studies with scores. | High | 4.8997 | BioGRID | 2456241 |
Curated By
- BioGRID