UBE2M
Gene Ontology Biological Process
Gene Ontology Molecular Function
CUL7
Gene Ontology Biological Process
- Golgi organization [ISS]
- activation of signaling protein activity involved in unfolded protein response [TAS]
- cellular protein metabolic process [TAS]
- endoplasmic reticulum unfolded protein response [TAS]
- epithelial to mesenchymal transition [IDA]
- microtubule cytoskeleton organization [IMP]
- mitotic cytokinesis [IMP]
- placenta development [IDA]
- positive regulation of dendrite morphogenesis [IGI, ISS]
- protein ubiquitination [IDA, TAS]
- proteolysis [NAS]
- regulation of mitosis [IMP]
- vasculogenesis [ISS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Biochemical Activity (Nedd(Rub1)ylation)
An interaction is inferred from the biochemical effect of one protein upon another, for example, GTP-GDP exchange activity or phosphorylation of a substrate by a kinase. The bait protein executes the activity on the substrate hit protein. A Modification value is recorded for interactions of this type with the possible values Phosphorylation, Ubiquitination, Sumoylation, Dephosphorylation, Methylation, Prenylation, Acetylation, Deubiquitination, Proteolytic Processing, Glucosylation, Nedd(Rub1)ylation, Deacetylation, No Modification, Demethylation.
Publication
Characterization of the Cullin7 E3 ubiquitin ligase - Heterodimerization of cullin substrate receptors as a novel mechanism to regulate cullin E3 ligase activity.
Cul1 and Cul7 are cullin E3 ubiquitin ligase scaffold proteins. Cul1 is known to form a complex with the RING domain protein Rbx1 and one of approximately 70 different F-box proteins. F-box proteins function as substrate receptor subunits and recruit numerous substrates for poly-ubiquitination. Similarly to Cul1, Cul7 interacts with Rbx1, however, only one F-box protein, Fbxw8, has been shown ... [more]
Throughput
- Low Throughput
Additional Notes
- in vitro neddylation assay of Cul1 or Cul7 by UbcH12
Curated By
- BioGRID