BAIT
YWHAE
AU019196, RP23-78H4.1
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide
GO Process (8)
GO Function (12)
GO Component (6)
Gene Ontology Biological Process
- cerebral cortex development [IMP]
- hippocampus development [IMP]
- negative regulation of peptidyl-serine dephosphorylation [ISO]
- negative regulation of protein dephosphorylation [IDA]
- neuron migration [IGI, IMP]
- protein targeting [IDA]
- regulation of membrane repolarization [ISO]
- regulation of potassium ion transmembrane transporter activity [ISO]
Gene Ontology Molecular Function- MHC class II protein complex binding [ISO]
- enzyme binding [ISO]
- histone deacetylase binding [ISO]
- ion channel binding [ISO]
- phosphoprotein binding [ISO]
- phosphoserine binding [ISO]
- poly(A) RNA binding [ISO]
- potassium channel regulator activity [ISO]
- protein binding [IPI]
- protein complex binding [ISO]
- protein domain specific binding [IDA]
- protein heterodimerization activity [ISO]
- MHC class II protein complex binding [ISO]
- enzyme binding [ISO]
- histone deacetylase binding [ISO]
- ion channel binding [ISO]
- phosphoprotein binding [ISO]
- phosphoserine binding [ISO]
- poly(A) RNA binding [ISO]
- potassium channel regulator activity [ISO]
- protein binding [IPI]
- protein complex binding [ISO]
- protein domain specific binding [IDA]
- protein heterodimerization activity [ISO]
Gene Ontology Cellular Component
Mus musculus
PREY
YBX1
1700102N10Rik, C79409, EF1A, MSY1, Nsep1, YB-1, dbpB, mYB-1a, RP24-363D14.2
Y box protein 1
GO Process (10)
GO Function (12)
GO Component (12)
Gene Ontology Biological Process
- CRD-mediated mRNA stabilization [ISO]
- in utero embryonic development [IGI, IMP]
- negative regulation of apoptotic process [ISO]
- negative regulation of insulin receptor signaling pathway [ISO]
- negative regulation of striated muscle cell differentiation [IDA]
- negative regulation of transcription from RNA polymerase II promoter [IDA, IGI, ISO]
- positive regulation of cell proliferation [ISO]
- positive regulation of transcription from RNA polymerase II promoter [ISO]
- regulation of transcription, DNA-templated [ISO]
- transcription from RNA polymerase II promoter [ISO]
Gene Ontology Molecular Function- DNA binding [ISO]
- RNA binding [ISO]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding [ISO]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [ISO]
- chromatin binding [IDA]
- mRNA binding [ISO]
- p53 binding [ISO]
- poly(A) RNA binding [ISO]
- protein binding [IPI]
- sequence-specific DNA binding [ISO]
- single-stranded DNA binding [IDA, ISO]
- transcription factor binding [ISO]
- DNA binding [ISO]
- RNA binding [ISO]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding [ISO]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [ISO]
- chromatin binding [IDA]
- mRNA binding [ISO]
- p53 binding [ISO]
- poly(A) RNA binding [ISO]
- protein binding [IPI]
- sequence-specific DNA binding [ISO]
- single-stranded DNA binding [IDA, ISO]
- transcription factor binding [ISO]
Gene Ontology Cellular Component
- CRD-mediated mRNA stability complex [ISO]
- U12-type spliceosomal complex [ISO]
- cytoplasm [IDA, ISO]
- cytoplasmic stress granule [ISO]
- dendrite [ISO]
- extracellular vesicular exosome [ISO]
- histone pre-mRNA 3'end processing complex [IDA]
- intracellular membrane-bounded organelle [ISO]
- nuclear membrane [ISO]
- nucleus [IGI, ISO]
- perinuclear region of cytoplasm [ISO]
- ribonucleoprotein complex [ISO]
Mus musculus
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Identification of 14-3-3epsilon substrates from embryonic murine brain.
Mice deficient in 14-3-3epsilon exhibit abnormal neuronal migration and die perinatally. We report here the first large-scale analysis of 14-3-3 interacting partners from primary animal tissue, identifying from embryonic murine brain 163 14-3-3epsilon interacting proteins and 85 phosphorylation sites on these proteins. Phosphorylation of the deubiquitinating enzyme USP8 at serine 680 was found essential for its interaction with 14-3-3epsilon and ... [more]
J. Proteome Res. Sep. 01, 2006; 5(9);2372-9 [Pubmed: 16944949]
Throughput
- High Throughput
Curated By
- BioGRID