YWHAE
Gene Ontology Biological Process
- cerebral cortex development [IMP]
- hippocampus development [IMP]
- negative regulation of peptidyl-serine dephosphorylation [ISO]
- negative regulation of protein dephosphorylation [IDA]
- neuron migration [IGI, IMP]
- protein targeting [IDA]
- regulation of membrane repolarization [ISO]
- regulation of potassium ion transmembrane transporter activity [ISO]
Gene Ontology Molecular Function- MHC class II protein complex binding [ISO]
- enzyme binding [ISO]
- histone deacetylase binding [ISO]
- ion channel binding [ISO]
- phosphoprotein binding [ISO]
- phosphoserine binding [ISO]
- poly(A) RNA binding [ISO]
- potassium channel regulator activity [ISO]
- protein binding [IPI]
- protein complex binding [ISO]
- protein domain specific binding [IDA]
- protein heterodimerization activity [ISO]
- MHC class II protein complex binding [ISO]
- enzyme binding [ISO]
- histone deacetylase binding [ISO]
- ion channel binding [ISO]
- phosphoprotein binding [ISO]
- phosphoserine binding [ISO]
- poly(A) RNA binding [ISO]
- potassium channel regulator activity [ISO]
- protein binding [IPI]
- protein complex binding [ISO]
- protein domain specific binding [IDA]
- protein heterodimerization activity [ISO]
Gene Ontology Cellular Component
CLTC
Gene Ontology Biological Process
- Golgi organization [ISO]
- mitotic nuclear division [ISO]
- negative regulation of hyaluronan biosynthetic process [ISO]
- negative regulation of protein localization to plasma membrane [ISO]
- osteoblast differentiation [ISO]
- receptor internalization [ISO]
- receptor-mediated endocytosis [ISO]
- spindle assembly involved in mitosis [ISO]
- transferrin transport [ISO]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- Myb complex [ISO]
- T-tubule [ISO]
- clathrin coat [ISO]
- clathrin complex [ISO]
- clathrin-coated vesicle [ISO]
- cytoplasm [ISO]
- extracellular vesicular exosome [ISO]
- focal adhesion [ISO]
- intracellular membrane-bounded organelle [ISO]
- membrane [ISO]
- membrane coat [IDA]
- mitochondrion [IDA]
- myelin sheath [IDA]
- protein complex [ISO]
- sarcolemma [ISO]
- spindle [ISO]
- terminal bouton [ISO]
- vesicle [ISO]
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Identification of 14-3-3epsilon substrates from embryonic murine brain.
Mice deficient in 14-3-3epsilon exhibit abnormal neuronal migration and die perinatally. We report here the first large-scale analysis of 14-3-3 interacting partners from primary animal tissue, identifying from embryonic murine brain 163 14-3-3epsilon interacting proteins and 85 phosphorylation sites on these proteins. Phosphorylation of the deubiquitinating enzyme USP8 at serine 680 was found essential for its interaction with 14-3-3epsilon and ... [more]
Throughput
- High Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| YWHAE CLTC | Co-fractionation Co-fractionation Interaction inferred from the presence of two or more protein subunits in a partially purified protein preparation. If co-fractionation is demonstrated between 3 or more proteins, then add them as a complex. | High | 0.72 | BioGRID | 2667833 |
Curated By
- BioGRID