BAIT
YWHAE
AU019196, RP23-78H4.1
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide
GO Process (8)
GO Function (12)
GO Component (6)
Gene Ontology Biological Process
- cerebral cortex development [IMP]
- hippocampus development [IMP]
- negative regulation of peptidyl-serine dephosphorylation [ISO]
- negative regulation of protein dephosphorylation [IDA]
- neuron migration [IGI, IMP]
- protein targeting [IDA]
- regulation of membrane repolarization [ISO]
- regulation of potassium ion transmembrane transporter activity [ISO]
Gene Ontology Molecular Function- MHC class II protein complex binding [ISO]
- enzyme binding [ISO]
- histone deacetylase binding [ISO]
- ion channel binding [ISO]
- phosphoprotein binding [ISO]
- phosphoserine binding [ISO]
- poly(A) RNA binding [ISO]
- potassium channel regulator activity [ISO]
- protein binding [IPI]
- protein complex binding [ISO]
- protein domain specific binding [IDA]
- protein heterodimerization activity [ISO]
- MHC class II protein complex binding [ISO]
- enzyme binding [ISO]
- histone deacetylase binding [ISO]
- ion channel binding [ISO]
- phosphoprotein binding [ISO]
- phosphoserine binding [ISO]
- poly(A) RNA binding [ISO]
- potassium channel regulator activity [ISO]
- protein binding [IPI]
- protein complex binding [ISO]
- protein domain specific binding [IDA]
- protein heterodimerization activity [ISO]
Gene Ontology Cellular Component
Mus musculus
PREY
BRSK2
4833424K13Rik, SAD-A, SADA
BR serine/threonine kinase 2
GO Process (10)
GO Function (6)
GO Component (2)
Gene Ontology Biological Process
- G2/M transition of mitotic cell cycle [ISO]
- actin cytoskeleton reorganization [ISO]
- axonogenesis [IMP]
- establishment of cell polarity [IGI, IMP]
- intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress [ISO]
- neuron differentiation [IGI]
- neuron projection morphogenesis [IGI]
- peptidyl-serine phosphorylation [IDA]
- protein phosphorylation [IDA, ISO, TAS]
- regulation of insulin secretion involved in cellular response to glucose stimulus [IMP, ISO]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Identification of 14-3-3epsilon substrates from embryonic murine brain.
Mice deficient in 14-3-3epsilon exhibit abnormal neuronal migration and die perinatally. We report here the first large-scale analysis of 14-3-3 interacting partners from primary animal tissue, identifying from embryonic murine brain 163 14-3-3epsilon interacting proteins and 85 phosphorylation sites on these proteins. Phosphorylation of the deubiquitinating enzyme USP8 at serine 680 was found essential for its interaction with 14-3-3epsilon and ... [more]
J. Proteome Res. Sep. 01, 2006; 5(9);2372-9 [Pubmed: 16944949]
Throughput
- High Throughput
Curated By
- BioGRID