BAIT

PIK3R5

F730038I15Rik, FOAP-2, P101-PI3K, p101

phosphoinositide-3-kinase, regulatory subunit 5

Cell Cycle - mTOR pathway Project

GO Process (9)

GO Function (1)

GO Component (4)

Gene Ontology Biological Process

G-protein coupled receptor signaling pathway [ISS]

blood coagulation [TAS]

phosphatidylinositol 3-kinase signaling [ISS]

phosphatidylinositol biosynthetic process [TAS]

phospholipid metabolic process [TAS]

platelet activation [TAS]

positive regulation of MAP kinase activity [ISS]

positive regulation of protein kinase B signaling [ISS]

small molecule metabolic process [TAS]

Gene Ontology Molecular Function

G-protein beta/gamma-subunit complex binding [ISS]

Gene Ontology Cellular Component

cytoplasm [ISS]

phosphatidylinositol 3-kinase complex, class IB [ISS]

CRISPR Database HGNC Alliance of Genome Resources OMIM Entrez Gene RefSeq UniprotKB Ensembl

Homo sapiens

PREY

SDHB

CWS2, IP, PGL4, SDH, SDH1, SDH2, SDHIP

succinate dehydrogenase complex, subunit B, iron sulfur (Ip)

GO Process (5)

GO Function (5)

GO Component (4)

Gene Ontology Biological Process

aerobic respiration [TAS]

cellular metabolic process [TAS]

respiratory electron transport chain [TAS]

small molecule metabolic process [TAS]

tricarboxylic acid cycle [TAS]

Gene Ontology Molecular Function

2 iron, 2 sulfur cluster binding [ISS]
3 iron, 4 sulfur cluster binding [ISS]
4 iron, 4 sulfur cluster binding [ISS]
protein binding [IPI]
ubiquinone binding [ISS]

Gene Ontology Cellular Component

extracellular vesicular exosome [IDA]

mitochondrial inner membrane [ISS, TAS]

mitochondrial respiratory chain complex II [ISS]

mitochondrion [IDA]

CRISPR Database OMIM HGNC Alliance of Genome Resources Entrez Gene RefSeq UniprotKB Ensembl

Homo sapiens

Two-hybrid

Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.

Publication

Protein interaction data set highlighted with human Ras-MAPK/PI3K signaling pathways.

Wang J, Yuan Y, Zhou Y, Guo L, Zhang L, Kuai X, Deng B, Pan Z, Li D, He F

The Ras-MAPK and PI3K-AKT pathways are conserved in metazoan organisms, which involve a series of signaling cascades and form the basis for numerous physiological and pathological processes. Here we report on yeast two hybrid screening results of a protein interaction network around the known components of human Ras-MAPK/PI3K pathways. A total of 42 independent cDNA library screenings resulted in 200 ... [more]

J. Proteome Res. Sep. 01, 2008; 7(9);3879-89 [Pubmed: 18624398]

Throughput

Low Throughput

Curated By

BioGRID