BAIT
PIK3CA
CLOVE, CWS5, MCAP, MCM, MCMTC, PI3K, p110-alpha
phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha
GO Process (22)
GO Function (6)
GO Component (4)
Gene Ontology Biological Process
- Fc-epsilon receptor signaling pathway [TAS]
- Fc-gamma receptor signaling pathway involved in phagocytosis [TAS]
- T cell costimulation [TAS]
- T cell receptor signaling pathway [TAS]
- blood coagulation [TAS]
- cardiac muscle contraction [TAS]
- endothelial cell migration [TAS]
- epidermal growth factor receptor signaling pathway [TAS]
- fibroblast growth factor receptor signaling pathway [TAS]
- innate immune response [TAS]
- insulin receptor signaling pathway [TAS]
- insulin receptor signaling pathway via phosphatidylinositol 3-kinase [TAS]
- leukocyte migration [TAS]
- negative regulation of anoikis [IMP]
- neurotrophin TRK receptor signaling pathway [TAS]
- phosphatidylinositol biosynthetic process [TAS]
- phosphatidylinositol phosphorylation [ISS]
- phosphatidylinositol-mediated signaling [TAS]
- phospholipid metabolic process [TAS]
- platelet activation [TAS]
- small molecule metabolic process [TAS]
- vasculature development [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
ATPIF1
ATPI, ATPIP, IP, RP5-1092A3.1
ATPase inhibitory factor 1
GO Process (8)
GO Function (6)
GO Component (3)
Gene Ontology Biological Process
- angiogenesis [TAS]
- erythrocyte differentiation [IMP]
- generation of precursor metabolites and energy [TAS]
- heme biosynthetic process [IMP]
- negative regulation of endothelial cell proliferation [IDA]
- negative regulation of hydrolase activity [IDA, ISS]
- protein homooligomerization [ISS]
- protein homotetramerization [ISS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Two-hybrid
Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.
Publication
Protein interaction data set highlighted with human Ras-MAPK/PI3K signaling pathways.
The Ras-MAPK and PI3K-AKT pathways are conserved in metazoan organisms, which involve a series of signaling cascades and form the basis for numerous physiological and pathological processes. Here we report on yeast two hybrid screening results of a protein interaction network around the known components of human Ras-MAPK/PI3K pathways. A total of 42 independent cDNA library screenings resulted in 200 ... [more]
J. Proteome Res. Sep. 01, 2008; 7(9);3879-89 [Pubmed: 18624398]
Throughput
- Low Throughput
Curated By
- BioGRID