BAIT
IRF1
IRF-1, MAR
interferon regulatory factor 1
GO Process (22)
GO Function (4)
GO Component (5)
Gene Ontology Biological Process
- apoptotic process [IDA]
- blood coagulation [TAS]
- cell cycle arrest [IDA]
- cellular response to interferon-beta [IDA]
- cellular response to mechanical stimulus [IEP]
- cytokine-mediated signaling pathway [TAS]
- defense response to virus [IDA]
- interferon-gamma-mediated signaling pathway [ISS, TAS]
- negative regulation of cell proliferation [TAS]
- negative regulation of regulatory T cell differentiation [ISS]
- negative regulation of transcription, DNA-templated [IMP]
- positive regulation of interferon-beta production [IMP]
- positive regulation of transcription from RNA polymerase II promoter [IMP]
- positive regulation of transcription, DNA-templated [IDA, IMP]
- positive regulation of type I interferon production [ISS]
- regulation of CD8-positive, alpha-beta T cell proliferation [ISS]
- regulation of MyD88-dependent toll-like receptor signaling pathway [ISS]
- regulation of adaptive immune response [TAS]
- regulation of cell cycle [TAS]
- regulation of innate immune response [TAS]
- transcription from RNA polymerase II promoter [TAS]
- type I interferon signaling pathway [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
TRAF3
CAP-1, CAP1, CD40bp, CRAF1, IIAE5, LAP1
TNF receptor-associated factor 3
GO Process (14)
GO Function (5)
GO Component (3)
Gene Ontology Biological Process
- MyD88-independent toll-like receptor signaling pathway [TAS]
- TRIF-dependent toll-like receptor signaling pathway [TAS]
- innate immune response [TAS]
- negative regulation of NF-kappaB transcription factor activity [IMP]
- negative regulation of type I interferon production [TAS]
- regulation of cytokine production [ISS]
- regulation of defense response to virus [ISS]
- regulation of interferon-beta production [ISS]
- regulation of proteolysis [IMP]
- signal transduction [TAS]
- toll-like receptor 3 signaling pathway [TAS]
- toll-like receptor 4 signaling pathway [TAS]
- toll-like receptor signaling pathway [ISS, TAS]
- tumor necrosis factor-mediated signaling pathway [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Reconstituted Complex
An interaction is detected between purified proteins in vitro.
Publication
Mapping a dynamic innate immunity protein interaction network regulating type I interferon production.
To systematically investigate innate immune signaling networks regulating production of type I interferon, we analyzed protein complexes formed after microbial recognition. Fifty-eight baits were associated with 260 interacting proteins forming a human innate immunity interactome for type I interferon (HI5) of 401 unique interactions; 21% of interactions were modulated by RNA, DNA, or LPS. Overexpression and depletion analyses identified 22 ... [more]
Immunity Sep. 23, 2011; 35(3);426-40 [Pubmed: 21903422]
Throughput
- Low Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| IRF1 TRAF3 | Affinity Capture-MS Affinity Capture-MS An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods. | High | - | BioGRID | 593996 |
Curated By
- BioGRID