BAIT
MAPK8IP2
IB-2, IB2, JIP2, PRKM8IPL
mitogen-activated protein kinase 8 interacting protein 2
GO Process (14)
GO Function (7)
GO Component (2)
Gene Ontology Biological Process
- MAPK cascade [IDA]
- behavioral fear response [ISS]
- dendrite morphogenesis [ISS]
- nonassociative learning [ISS]
- positive regulation of protein kinase activity [IDA, IGI]
- positive regulation of signal transduction [NAS]
- regulation of JNK cascade [IDA]
- regulation of N-methyl-D-aspartate selective glutamate receptor activity [ISS]
- regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity [ISS]
- regulation of excitatory postsynaptic membrane potential [ISS]
- regulation of receptor activity [ISS]
- regulation of synaptic transmission, glutamatergic [ISS]
- signal complex assembly [TAS]
- social behavior [ISS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
RPS6KB2
KLS, P70-beta, P70-beta-1, P70-beta-2, S6K-beta2, S6K2, SRK, STK14B, p70(S6K)-beta, p70S6Kb
ribosomal protein S6 kinase, 70kDa, polypeptide 2
GO Process (9)
GO Function (2)
GO Component (1)
Gene Ontology Biological Process
- Fc-epsilon receptor signaling pathway [TAS]
- epidermal growth factor receptor signaling pathway [TAS]
- fibroblast growth factor receptor signaling pathway [TAS]
- innate immune response [TAS]
- neurotrophin TRK receptor signaling pathway [TAS]
- phosphatidylinositol-mediated signaling [TAS]
- positive regulation of translational initiation [IMP]
- signal transduction [TAS]
- translation [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Two-hybrid
Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.
Publication
A directed protein interaction network for investigating intracellular signal transduction.
Cellular signal transduction is a complex process involving protein-protein interactions (PPIs) that transmit information. For example, signals from the plasma membrane may be transduced to transcription factors to regulate gene expression. To obtain a global view of cellular signaling and to predict potential signal modulators, we searched for protein interaction partners of more than 450 signaling-related proteins by means of ... [more]
Sci Signal Sep. 06, 2011; 4(189);rs8 [Pubmed: 21900206]
Throughput
- High Throughput
Curated By
- BioGRID