BAIT
CCL21
6Ckine, CKb9, ECL, SCYA21, SLC, TCA4, RP11-195F19.22-001
chemokine (C-C motif) ligand 21
GO Process (37)
GO Function (3)
GO Component (1)
Gene Ontology Biological Process
- G-protein coupled receptor signaling pathway [IDA]
- T cell costimulation [ISS]
- activation of Rho GTPase activity [IDA]
- cell chemotaxis [IDA]
- cell maturation [ISS]
- cell-cell signaling [TAS]
- dendritic cell chemotaxis [IDA]
- dendritic cell dendrite assembly [ISS]
- establishment of T cell polarity [IDA]
- immunological synapse formation [ISS]
- inflammatory response [NAS]
- mesangial cell-matrix adhesion [IDA]
- negative regulation of dendritic cell dendrite assembly [ISS]
- negative regulation of leukocyte apoptotic process [IDA]
- negative regulation of leukocyte tethering or rolling [IDA]
- positive regulation of ERK1 and ERK2 cascade [IDA]
- positive regulation of I-kappaB kinase/NF-kappaB signaling [IDA]
- positive regulation of JNK cascade [IDA]
- positive regulation of T cell migration [IDA]
- positive regulation of actin filament polymerization [IDA]
- positive regulation of cell adhesion mediated by integrin [IDA]
- positive regulation of cell motility [IDA]
- positive regulation of cell-matrix adhesion [IDA]
- positive regulation of chemotaxis [ISS]
- positive regulation of dendritic cell antigen processing and presentation [ISS]
- positive regulation of filopodium assembly [IDA]
- positive regulation of glycoprotein biosynthetic process [ISS]
- positive regulation of myeloid dendritic cell chemotaxis [IDA]
- positive regulation of neutrophil chemotaxis [IDA]
- positive regulation of phosphatidylinositol 3-kinase activity [IDA]
- positive regulation of protein kinase B signaling [IDA]
- positive regulation of protein kinase activity [IDA]
- positive regulation of pseudopodium assembly [IDA]
- positive regulation of receptor-mediated endocytosis [ISS]
- release of sequestered calcium ion into cytosol [IDA]
- response to prostaglandin E [IDA]
- ruffle organization [IDA]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
GOT2
KAT4, KATIV, mitAAT
glutamic-oxaloacetic transaminase 2, mitochondrial
GO Process (13)
GO Function (2)
GO Component (4)
Gene Ontology Biological Process
- 2-oxoglutarate metabolic process [ISS]
- 4-hydroxyproline catabolic process [TAS]
- aspartate catabolic process [IDA]
- aspartate metabolic process [ISS]
- carbohydrate metabolic process [TAS]
- cellular amino acid biosynthetic process [TAS]
- cellular nitrogen compound metabolic process [TAS]
- fatty acid transport [IEP]
- gluconeogenesis [TAS]
- glucose metabolic process [TAS]
- glutamate metabolic process [ISS]
- response to ethanol [IDA]
- small molecule metabolic process [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Two-hybrid
Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.
Publication
A directed protein interaction network for investigating intracellular signal transduction.
Cellular signal transduction is a complex process involving protein-protein interactions (PPIs) that transmit information. For example, signals from the plasma membrane may be transduced to transcription factors to regulate gene expression. To obtain a global view of cellular signaling and to predict potential signal modulators, we searched for protein interaction partners of more than 450 signaling-related proteins by means of ... [more]
Sci Signal Sep. 06, 2011; 4(189);rs8 [Pubmed: 21900206]
Throughput
- High Throughput
Curated By
- BioGRID