BAIT
MAPK6
ERK3, HsT17250, PRKM6, p97MAPK
mitogen-activated protein kinase 6
GO Process (3)
GO Function (3)
GO Component (2)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Homo sapiens
PREY
SNW1
Bx42, NCOA-62, PRPF45, Prp45, SKIIP, SKIP
SNW domain containing 1
GO Process (19)
GO Function (9)
GO Component (7)
Gene Ontology Biological Process
- Notch signaling pathway [TAS]
- cellular response to retinoic acid [IDA]
- gene expression [TAS]
- intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator [IMP]
- mRNA splicing, via spliceosome [IC, IDA]
- negative regulation of transcription from RNA polymerase II promoter [IDA]
- negative regulation of transcription, DNA-templated [IDA]
- positive regulation by host of viral transcription [IDA, IMP]
- positive regulation of histone H3-K4 methylation [IMP]
- positive regulation of mRNA splicing, via spliceosome [IMP]
- positive regulation of neurogenesis [ISS]
- positive regulation of transcription from RNA polymerase II promoter [IDA]
- positive regulation of transforming growth factor beta receptor signaling pathway [IDA]
- positive regulation of vitamin D receptor signaling pathway [IDA]
- regulation of retinoic acid receptor signaling pathway [IDA]
- regulation of transcription from RNA polymerase II promoter [TAS]
- regulation of vitamin D receptor signaling pathway [IDA]
- retinoic acid receptor signaling pathway [IDA]
- transcription initiation from RNA polymerase II promoter [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Two-hybrid
Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.
Publication
A directed protein interaction network for investigating intracellular signal transduction.
Cellular signal transduction is a complex process involving protein-protein interactions (PPIs) that transmit information. For example, signals from the plasma membrane may be transduced to transcription factors to regulate gene expression. To obtain a global view of cellular signaling and to predict potential signal modulators, we searched for protein interaction partners of more than 450 signaling-related proteins by means of ... [more]
Sci Signal Sep. 06, 2011; 4(189);rs8 [Pubmed: 21900206]
Throughput
- High Throughput
Curated By
- BioGRID