BAIT
RPS6KA6
PP90RSK4, RSK4
ribosomal protein S6 kinase, 90kDa, polypeptide 6
GO Process (8)
GO Function (1)
GO Component (5)
Gene Ontology Biological Process
- DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator [IMP]
- axon guidance [TAS]
- central nervous system development [TAS]
- negative regulation of ERK1 and ERK2 cascade [ISS]
- negative regulation of embryonic development [ISS]
- negative regulation of mesoderm development [ISS]
- signal transduction [TAS]
- synaptic transmission [TAS]
Gene Ontology Molecular Function
Homo sapiens
Two-hybrid
Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.
Publication
A directed protein interaction network for investigating intracellular signal transduction.
Cellular signal transduction is a complex process involving protein-protein interactions (PPIs) that transmit information. For example, signals from the plasma membrane may be transduced to transcription factors to regulate gene expression. To obtain a global view of cellular signaling and to predict potential signal modulators, we searched for protein interaction partners of more than 450 signaling-related proteins by means of ... [more]
Sci Signal Sep. 06, 2011; 4(189);rs8 [Pubmed: 21900206]
Throughput
- High Throughput
Curated By
- BioGRID