YWHAZ
Gene Ontology Biological Process
- Golgi reassembly [IMP]
- RNA metabolic process [TAS]
- apoptotic process [TAS]
- blood coagulation [TAS]
- establishment of Golgi localization [IMP]
- gene expression [TAS]
- intrinsic apoptotic signaling pathway [TAS]
- mRNA metabolic process [TAS]
- membrane organization [TAS]
- negative regulation of apoptotic process [TAS]
- platelet activation [TAS]
- positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway [TAS]
- signal transduction [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
KAT8
Gene Ontology Biological Process
- chromatin organization [TAS]
- histone H4-K16 acetylation [IDA, IMP]
- histone H4-K5 acetylation [IDA]
- histone H4-K8 acetylation [IDA]
- histone acetylation [IDA]
- myeloid cell differentiation [IDA]
- negative regulation of transcription, DNA-templated [IDA]
- positive regulation of transcription, DNA-templated [IDA, IMP]
- regulation of autophagy [IDA]
Gene Ontology Molecular Function- acetyltransferase activity [IDA]
- histone acetyltransferase activity [IDA]
- histone acetyltransferase activity (H4-K16 specific) [IDA]
- histone acetyltransferase activity (H4-K5 specific) [IDA]
- histone acetyltransferase activity (H4-K8 specific) [IDA]
- methylated histone binding [IDA]
- protein binding [IPI]
- transcription factor binding [IDA]
- acetyltransferase activity [IDA]
- histone acetyltransferase activity [IDA]
- histone acetyltransferase activity (H4-K16 specific) [IDA]
- histone acetyltransferase activity (H4-K5 specific) [IDA]
- histone acetyltransferase activity (H4-K8 specific) [IDA]
- methylated histone binding [IDA]
- protein binding [IPI]
- transcription factor binding [IDA]
Gene Ontology Cellular Component
Co-localization
Interaction inferred from two proteins that co-localize in the cell by indirect immunofluorescence only when in addition, if one gene is deleted, the other protein becomes mis-localized. Also includes co-dependent association of proteins with promoter DNA in chromatin immunoprecipitation experiments.
Publication
Histone crosstalk between H3S10ph and H4K16ac generates a histone code that mediates transcription elongation.
The phosphorylation of the serine 10 at histone H3 has been shown to be important for transcriptional activation. Here, we report the molecular mechanism through which H3S10ph triggers transcript elongation of the FOSL1 gene. Serum stimulation induces the PIM1 kinase to phosphorylate the preacetylated histone H3 at the FOSL1 enhancer. The adaptor protein 14-3-3 binds the phosphorylated nucleosome and recruits ... [more]
Throughput
- Low Throughput
Additional Notes
- ChIP
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| YWHAZ KAT8 | Affinity Capture-Western Affinity Capture-Western An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins. | Low | - | BioGRID | - | |
| KAT8 YWHAZ | Affinity Capture-Western Affinity Capture-Western An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins. | Low | - | BioGRID | - |
Curated By
- BioGRID