BAIT
TLR4
Lps, Ly87, Ran/M1, Rasl2-8, RP24-209H15.1
toll-like receptor 4
GO Process (71)
GO Function (5)
GO Component (8)
Gene Ontology Biological Process
- B cell proliferation involved in immune response [IMP]
- I-kappaB phosphorylation [IMP, ISO]
- activation of MAPK activity [IMP]
- activation of NF-kappaB-inducing kinase activity [NAS]
- activation of innate immune response [IMP]
- cellular response to lipopolysaccharide [IDA, IMP]
- cellular response to lipoteichoic acid [IMP]
- defense response to Gram-negative bacterium [IMP]
- detection of lipopolysaccharide [ISO, TAS]
- innate immune response [TAS]
- innate immune response-activating signal transduction [ISO]
- interferon-gamma production [IGI]
- intestinal epithelial structure maintenance [IMP]
- leukotriene metabolic process [ISO]
- lipopolysaccharide-mediated signaling pathway [IDA, IGI, ISO]
- macrophage activation [ISO, ISS]
- mast cell activation [NAS]
- microglial cell activation [ISO]
- negative regulation of ERK1 and ERK2 cascade [IMP]
- negative regulation of interferon-gamma production [IMP]
- negative regulation of interleukin-17 production [IMP]
- negative regulation of interleukin-23 production [IMP]
- negative regulation of interleukin-6 production [IMP]
- negative regulation of tumor necrosis factor production [IMP]
- nitric oxide production involved in inflammatory response [IMP]
- positive regulation of B cell proliferation [IMP]
- positive regulation of DNA binding [ISO]
- positive regulation of ERK1 and ERK2 cascade [IDA]
- positive regulation of I-kappaB kinase/NF-kappaB signaling [IDA]
- positive regulation of JNK cascade [IDA, IGI]
- positive regulation of MHC class II biosynthetic process [IMP]
- positive regulation of NF-kappaB import into nucleus [ISO]
- positive regulation of NF-kappaB transcription factor activity [ISO]
- positive regulation of apoptotic process [ISO]
- positive regulation of chemokine production [IDA, ISO]
- positive regulation of inflammatory response [ISO]
- positive regulation of interferon-alpha production [IDA]
- positive regulation of interferon-beta biosynthetic process [IMP]
- positive regulation of interferon-beta production [IDA]
- positive regulation of interferon-gamma production [IMP]
- positive regulation of interleukin-1 biosynthetic process [NAS]
- positive regulation of interleukin-1 production [IDA]
- positive regulation of interleukin-10 production [IDA]
- positive regulation of interleukin-12 biosynthetic process [ISO]
- positive regulation of interleukin-12 production [IDA]
- positive regulation of interleukin-13 biosynthetic process [NAS]
- positive regulation of interleukin-6 biosynthetic process [NAS]
- positive regulation of interleukin-6 production [IDA, IMP, ISO, NAS]
- positive regulation of interleukin-8 biosynthetic process [ISO]
- positive regulation of interleukin-8 production [ISO]
- positive regulation of lymphocyte proliferation [IMP]
- positive regulation of macrophage cytokine production [IMP]
- positive regulation of nitric oxide biosynthetic process [IMP]
- positive regulation of nitric-oxide synthase biosynthetic process [IDA]
- positive regulation of nucleotide-binding oligomerization domain containing 1 signaling pathway [IDA]
- positive regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway [IDA]
- positive regulation of peptidyl-tyrosine phosphorylation [ISO]
- positive regulation of platelet activation [IMP]
- positive regulation of sequence-specific DNA binding transcription factor activity [ISO]
- positive regulation of stress-activated MAPK cascade [IDA]
- positive regulation of transcription from RNA polymerase II promoter [IDA]
- positive regulation of tumor necrosis factor biosynthetic process [ISO]
- positive regulation of tumor necrosis factor production [IDA, IMP]
- regulation of inflammatory response [IMP]
- regulation of sensory perception of pain [ISO]
- response to bacterium [IMP]
- response to ethanol [ISO]
- response to fatty acid [ISO]
- response to lipopolysaccharide [IGI, IMP, ISO]
- response to oxidative stress [ISO]
- toll-like receptor signaling pathway [ISO]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
PREY
TRAF3
AI528849, CAP-1, CD40bp, CRAF1, LAP1, T-BAM, amn
TNF receptor-associated factor 3
GO Process (7)
GO Function (5)
GO Component (2)
Gene Ontology Biological Process
- negative regulation of NF-kappaB transcription factor activity [IMP, ISO, TAS]
- regulation of cytokine production [IMP]
- regulation of defense response to virus [IMP]
- regulation of interferon-beta production [IMP]
- regulation of proteolysis [IDA, IMP, ISO]
- toll-like receptor signaling pathway [IMP]
- tumor necrosis factor-mediated signaling pathway [IMP, ISO]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
Different modes of ubiquitination of the adaptor TRAF3 selectively activate the expression of type I interferons and proinflammatory cytokines.
Balanced production of type I interferons and proinflammatory cytokines after engagement of Toll-like receptors (TLRs), which signal through adaptors containing a Toll-interleukin 1 receptor (TIR) domain, such as MyD88 and TRIF, has been proposed to control the pathogenesis of autoimmune disease and tumor responses to inflammation. Here we show that TRAF3, a ubiquitin ligase that interacts with both MyD88 and ... [more]
Nat. Immunol. Jan. 01, 2010; 11(1);70-5 [Pubmed: 19898473]
Throughput
- Low Throughput
Curated By
- BioGRID