BAIT
TRPV4
CMT2C, HMSN2C, OTRPC4, SMAL, SPSMA, SSQTL1, TRP12, VRL2, VROAC
transient receptor potential cation channel, subfamily V, member 4
GO Process (20)
GO Function (11)
GO Component (10)
Gene Ontology Biological Process
- actin cytoskeleton reorganization [ISS]
- actin filament organization [ISS]
- calcium ion import [ISS]
- calcium ion transmembrane transport [TAS]
- calcium ion transport [IDA, NAS]
- cell volume homeostasis [TAS]
- cell-cell junction assembly [ISS]
- cellular calcium ion homeostasis [IDA]
- cellular hypotonic response [ISS]
- cellular response to heat [ISS]
- cellular response to osmotic stress [ISS]
- cortical microtubule organization [ISS]
- ion transmembrane transport [TAS]
- microtubule polymerization [ISS]
- negative regulation of neuron projection development [ISS]
- osmosensory signaling pathway [ISS, TAS]
- positive regulation of cytosolic calcium ion concentration [IDA]
- positive regulation of microtubule depolymerization [ISS]
- response to mechanical stimulus [TAS]
- transmembrane transport [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
KRIT1
CAM, CCM1
KRIT1, ankyrin repeat containing
GO Process (8)
GO Function (5)
GO Component (4)
Gene Ontology Biological Process
- cell redox homeostasis [IMP]
- negative regulation of angiogenesis [IMP]
- negative regulation of endothelial cell apoptotic process [IMP]
- negative regulation of endothelial cell migration [IMP]
- negative regulation of endothelial cell proliferation [IMP]
- regulation of catalytic activity [TAS]
- regulation of establishment of cell polarity [IMP]
- small GTPase mediated signal transduction [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Protein-peptide
An interaction is detected between a protein and a peptide derived from an interaction partner. This includes phage display experiments.
Publication
Ca2+-dependent potentiation of the nonselective cation channel TRPV4 is mediated by a C-terminal calmodulin binding site.
Most Ca2+-permeable ion channels are inhibited by increases in the intracellular Ca2+ concentration ([Ca2+]i), thus preventing potentially deleterious rises in [Ca2+]i. In this study, we demonstrate that currents through the osmo-, heat- and phorbol ester-sensitive, Ca2+-permeable nonselective cation channel TRPV4 are potentiated by intracellular Ca2+. Spontaneous TRPV4 currents and currents stimulated by hypotonic solutions or phorbol esters were reduced strongly ... [more]
J. Biol. Chem. Jul. 18, 2003; 278(29);26541-9 [Pubmed: 12724311]
Throughput
- Low Throughput
Curated By
- BioGRID