TRAF2
Gene Ontology Biological Process
- activation of NF-kappaB-inducing kinase activity [ISO]
- cellular protein complex assembly [IDA]
- cellular response to nitric oxide [IMP]
- negative regulation of apoptotic process [NAS]
- negative regulation of glial cell apoptotic process [ISO]
- positive regulation of JUN kinase activity [ISO]
- positive regulation of NF-kappaB transcription factor activity [IMP, ISO]
- positive regulation of T cell cytokine production [ISO]
- positive regulation of extrinsic apoptotic signaling pathway [ISO]
- positive regulation of interleukin-2 production [ISO]
- positive regulation of protein homodimerization activity [ISO]
- positive regulation of sequence-specific DNA binding transcription factor activity [ISO]
- programmed necrotic cell death [IMP]
- protein K63-linked ubiquitination [ISO]
- protein autoubiquitination [ISO]
- protein catabolic process [IMP]
- protein complex assembly [ISO]
- protein heterooligomerization [ISO]
- protein homotrimerization [ISO]
- regulation of JNK cascade [IDA]
- regulation of apoptotic process [ISO]
- regulation of immunoglobulin secretion [IMP]
- signal transduction [IDA]
- tumor necrosis factor-mediated signaling pathway [ISO]
Gene Ontology Molecular Function- CD40 receptor binding [IPI]
- enzyme binding [ISO]
- identical protein binding [ISO]
- mitogen-activated protein kinase kinase kinase binding [ISO]
- protein binding [IPI]
- protein complex binding [ISO]
- protein phosphatase binding [ISO]
- receptor binding [ISO]
- sphingolipid binding [ISO]
- thioesterase binding [ISO]
- tumor necrosis factor receptor binding [ISO]
- ubiquitin protein ligase binding [ISO]
- ubiquitin-protein transferase activity [ISO]
- CD40 receptor binding [IPI]
- enzyme binding [ISO]
- identical protein binding [ISO]
- mitogen-activated protein kinase kinase kinase binding [ISO]
- protein binding [IPI]
- protein complex binding [ISO]
- protein phosphatase binding [ISO]
- receptor binding [ISO]
- sphingolipid binding [ISO]
- thioesterase binding [ISO]
- tumor necrosis factor receptor binding [ISO]
- ubiquitin protein ligase binding [ISO]
- ubiquitin-protein transferase activity [ISO]
Gene Ontology Cellular Component
UBE2N
Gene Ontology Biological Process
- DNA double-strand break processing [ISO]
- T cell receptor signaling pathway [ISO, ISS]
- double-strand break repair via homologous recombination [ISO]
- histone ubiquitination [ISO]
- positive regulation of DNA repair [ISO]
- positive regulation of I-kappaB kinase/NF-kappaB signaling [ISO]
- positive regulation of NF-kappaB transcription factor activity [ISO, ISS]
- positive regulation of histone modification [ISO]
- positive regulation of ubiquitin-protein transferase activity [ISO]
- postreplication repair [IBA, ISO]
- protein K63-linked ubiquitination [IBA, ISO]
- protein ubiquitination [ISO]
- regulation of histone ubiquitination [ISO]
- ubiquitin-dependent protein catabolic process [IDA]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
The kinase IKKα inhibits activation of the transcription factor NF-κB by phosphorylating the regulatory molecule TAX1BP1.
In response to stimulation with proinflammatory cytokines, the deubiquitinase A20 inducibly interacts with the regulatory molecules TAX1BP1, Itch and RNF11 to form the A20 ubiquitin-editing complex. However, the molecular signal that coordinates the assembly of this complex has remained elusive. Here we demonstrate that TAX1BP1 was inducibly phosphorylated on Ser593 and Ser624 in response to proinflammatory stimuli. The kinase IKKα, ... [more]
Throughput
- Low Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| TRAF2 UBE2N | Affinity Capture-Western Affinity Capture-Western An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins. | Low | - | BioGRID | - |
Curated By
- BioGRID