RAD21
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
PPP1R15A
Gene Ontology Biological Process
- cell cycle arrest [TAS]
- cellular response to DNA damage stimulus [TAS]
- negative regulation of phosphoprotein phosphatase activity [IDA]
- negative regulation of protein dephosphorylation [IDA]
- negative regulation of transforming growth factor beta receptor signaling pathway [TAS]
- positive regulation of gene expression [IMP]
- positive regulation of peptidyl-serine dephosphorylation [IDA]
- positive regulation of peptidyl-serine phosphorylation [IMP]
- positive regulation of phosphoprotein phosphatase activity [IDA]
- positive regulation of transcription from RNA polymerase I promoter [IGI]
- positive regulation of translational initiation in response to stress [IC]
- protein localization to endoplasmic reticulum [IMP]
- transforming growth factor beta receptor signaling pathway [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
A Cohesin-RAD21 Interactome.
The cohesin complex holds the sister chromatids together from S phase until the metaphase-to-anaphase transition and ensures both their proper cohesin and timely separation. In addition to its canonical function in chromosomal segregation, cohesion has been suggested by several lines of investigation in recent years to play additional roles in apoptosis, DNA damage response, transcriptional regulation, and hematopoiesis. To better ... [more]
Throughput
- High Throughput
Ontology Terms
- molt-4 cell (BTO:0000873) [acute t cell leukemia (DOID:5603)]
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| RAD21 PPP1R15A | Two-hybrid Two-hybrid Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation. | High | - | BioGRID | - |
Curated By
- BioGRID