BAIT
NPHS1
nephrosis 1, congenital, Finnish type (nephrin)
GO Process (10)
GO Function (5)
GO Component (8)
Gene Ontology Biological Process
- JNK cascade [ISO]
- MAPK cascade [ISO]
- cell adhesion [ISO]
- glomerular basement membrane development [ISO]
- glomerular filtration [IC]
- glomerular visceral epithelial cell development [ISO]
- myoblast fusion [ISO]
- positive regulation of actin filament polymerization [ISO]
- regulation of excretion [ISO]
- skeletal muscle tissue development [ISO]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Rattus norvegicus
PREY
CASK
calcium/calmodulin-dependent serine protein kinase (MAGUK family)
GO Process (10)
GO Function (8)
GO Component (18)
Gene Ontology Biological Process
- calcium ion import [ISO]
- intracellular protein transport [IMP]
- negative regulation of cell-matrix adhesion [ISO]
- negative regulation of cellular response to growth factor stimulus [ISO]
- negative regulation of keratinocyte proliferation [ISO]
- negative regulation of wound healing [ISO]
- positive regulation of calcium ion import [ISO]
- positive regulation of transcription from RNA polymerase II promoter [ISO]
- protein complex assembly [TAS]
- regulation of nucleic acid-templated transcription [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- basement membrane [ISO]
- basolateral plasma membrane [ISO]
- cell-cell junction [ISO]
- ciliary membrane [IDA]
- cytoplasm [IDA, ISO]
- cytosol [ISO, TAS]
- dendrite [IDA]
- focal adhesion [ISO]
- membrane [IDA, ISO]
- nuclear lamina [ISO]
- nuclear matrix [ISO]
- nucleolus [ISO]
- nucleus [IDA, ISO]
- plasma membrane [IDA]
- presynaptic membrane [IDA]
- protein complex [IDA]
- synapse [ISO]
- synaptic membrane [IDA]
Rattus norvegicus
Reconstituted Complex
An interaction is detected between purified proteins in vitro.
Publication
Nephrin forms a complex with adherens junction proteins and CASK in podocytes and in Madin-Darby canine kidney cells expressing nephrin.
Mutations in the NPHS1 gene encoding nephrin lead to congenital nephrotic syndrome of the Finnish type. Nephrin is a key component of the glomerular slit diaphragms between epithelial foot processes, but its role in the pathogenesis of this disease is poorly understood. To further clarify the molecular mechanisms involved we investigated the interactions between nephrin and other components of the ... [more]
Am. J. Pathol. Sep. 01, 2004; 165(3);923-36 [Pubmed: 15331416]
Throughput
- Low Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| NPHS1 CASK | Affinity Capture-MS Affinity Capture-MS An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods. | Low | - | BioGRID | - |
Curated By
- BioGRID