STX2
Gene Ontology Biological Process
- acrosome reaction [ISO]
- cell differentiation [ISO]
- digestive tract morphogenesis [IMP]
- epithelial cell differentiation [IMP]
- intracellular protein transport [IBA]
- intracellular transport [TAS]
- microvillus assembly [IDA]
- protein oligomerization [ISO]
- regulation of blood coagulation [ISO]
- regulation of cytoskeleton organization [ISO]
- response to hydroperoxide [ISO]
- synaptic vesicle fusion to presynaptic membrane [IBA]
- vesicle docking [IBA]
- vesicle fusion [TAS]
- vesicle targeting [TAS]
- vesicle-mediated transport [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- SNARE complex [IBA]
- basolateral plasma membrane [ISO]
- cell surface [ISO]
- cell-cell junction [ISO]
- cytoplasmic vesicle [ISO]
- extracellular space [ISO]
- extracellular vesicular exosome [ISO]
- integral component of membrane [IBA, TAS]
- lamellipodium [ISO]
- membrane raft [ISO]
- midbody [IDA]
- plasma membrane [IBA, ISO]
- synaptic vesicle [IBA]
- transport vesicle [IDA]
STXBP1
Gene Ontology Biological Process
- axon target recognition [ISO]
- exocytosis [ISO]
- long term synaptic depression [ISO]
- negative regulation of neuron apoptotic process [ISO]
- negative regulation of synaptic transmission, GABAergic [ISO]
- neuromuscular synaptic transmission [ISO]
- neurotransmitter secretion [ISO]
- platelet aggregation [ISO]
- platelet degranulation [ISO]
- positive regulation of calcium ion-dependent exocytosis [ISO]
- positive regulation of exocytosis [IMP]
- protein localization to plasma membrane [ISO]
- protein stabilization [IDA]
- regulation of synaptic vesicle priming [IMP]
- synaptic vesicle maturation [ISO]
- vesicle docking involved in exocytosis [ISO]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Reconstituted Complex
An interaction is detected between purified proteins in vitro.
Publication
Mammalian homologues of yeast vacuolar protein sorting (vps) genes implicated in Golgi-to-lysosome trafficking.
Sec1p, Vps33p, Vps45p and Sly1p constitute a family of proteins implicated in vesicle trafficking at distinct stages of the yeast secretory pathway. Several mammalian homologues of Sec1p have been described, including n-sec1 which has been implicated in the regulation of synaptic vesicle docking at the nerve terminal. We have characterized cDNA clones encoding three additional mammalian homologues belonging to this ... [more]
Throughput
- Low Throughput
Additional Notes
- Stx2 could be Stx1b
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| STX2 STXBP1 | Reconstituted Complex Reconstituted Complex An interaction is detected between purified proteins in vitro. | Low | - | BioGRID | 616237 | |
| STX2 STXBP1 | Two-hybrid Two-hybrid Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation. | Low | - | BioGRID | 616226 | |
| STXBP1 STX2 | Two-hybrid Two-hybrid Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation. | Low | - | BioGRID | 616227 |
Curated By
- BioGRID