BAIT
APOE
AD2, APO-E, LDLCQ5, LPG
apolipoprotein E
GO Process (68)
GO Function (14)
GO Component (19)
Gene Ontology Biological Process
- G-protein coupled receptor signaling pathway [IDA]
- N-methyl-D-aspartate receptor clustering [IDA]
- alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor clustering [IDA]
- cGMP-mediated signaling [IDA]
- cholesterol efflux [IDA]
- cholesterol homeostasis [IDA]
- cholesterol metabolic process [IDA, IMP]
- chylomicron remnant clearance [IMP]
- cytoskeleton organization [TAS]
- fatty acid homeostasis [IDA]
- high-density lipoprotein particle assembly [IDA]
- high-density lipoprotein particle clearance [IDA]
- high-density lipoprotein particle remodeling [IGI]
- intracellular transport [TAS]
- lipoprotein metabolic process [TAS]
- long-chain fatty acid transport [IDA]
- negative regulation of MAP kinase activity [IDA]
- negative regulation of beta-amyloid formation [IDA]
- negative regulation of blood coagulation [IDA]
- negative regulation of blood vessel endothelial cell migration [IDA]
- negative regulation of cholesterol biosynthetic process [IDA]
- negative regulation of cholesterol efflux [IDA]
- negative regulation of dendritic spine development [IDA]
- negative regulation of dendritic spine maintenance [IDA]
- negative regulation of endothelial cell proliferation [IDA]
- negative regulation of inflammatory response [IC]
- negative regulation of lipid biosynthetic process [IDA]
- negative regulation of lipid transport across blood brain barrier [IDA]
- negative regulation of neuron death [IDA]
- negative regulation of phospholipid efflux [IDA]
- negative regulation of platelet activation [IDA]
- negative regulation of postsynaptic membrane organization [IDA]
- negative regulation of presynaptic membrane organization [IDA]
- nitric oxide mediated signal transduction [IDA]
- phospholipid efflux [IDA]
- phototransduction, visible light [TAS]
- positive regulation of beta-amyloid formation [IDA]
- positive regulation of cGMP biosynthetic process [IDA]
- positive regulation of cholesterol efflux [IDA, IGI]
- positive regulation of cholesterol esterification [IDA]
- positive regulation of dendritic spine development [IDA]
- positive regulation of dendritic spine maintenance [IDA]
- positive regulation of lipid biosynthetic process [IDA]
- positive regulation of lipid transport across blood brain barrier [IDA]
- positive regulation of low-density lipoprotein particle receptor catabolic process [IDA]
- positive regulation of membrane protein ectodomain proteolysis [IDA]
- positive regulation of neurofibrillary tangle assembly [IDA]
- positive regulation of neuron death [IDA]
- positive regulation of nitric-oxide synthase activity [IDA]
- positive regulation of phospholipid efflux [IDA]
- positive regulation of postsynaptic membrane organization [IDA]
- positive regulation of presynaptic membrane organization [IDA]
- protein import [IDA]
- receptor-mediated endocytosis [IDA]
- regulation of Cdc42 protein signal transduction [IDA]
- regulation of axon extension [TAS]
- regulation of beta-amyloid clearance [IDA]
- regulation of neuron death [IDA]
- regulation of neuronal synaptic plasticity [TAS]
- regulation of tau-protein kinase activity [IDA]
- response to reactive oxygen species [NAS]
- retinoid metabolic process [TAS]
- reverse cholesterol transport [IDA]
- small molecule metabolic process [TAS]
- synaptic transmission, cholinergic [TAS]
- triglyceride metabolic process [IDA, IMP]
- very-low-density lipoprotein particle clearance [IDA, IMP]
- very-low-density lipoprotein particle remodeling [IDA, IGI]
Gene Ontology Molecular Function- antioxidant activity [IDA]
- beta-amyloid binding [IDA]
- heparin binding [IDA]
- identical protein binding [IDA]
- lipid binding [IDA]
- lipid transporter activity [IDA]
- low-density lipoprotein particle receptor binding [IDA, IPI]
- metal chelating activity [IDA]
- phosphatidylcholine-sterol O-acyltransferase activator activity [IDA]
- phospholipid binding [IDA]
- protein binding [IPI]
- protein homodimerization activity [IPI]
- tau protein binding [IPI]
- very-low-density lipoprotein particle receptor binding [IDA, IPI]
- antioxidant activity [IDA]
- beta-amyloid binding [IDA]
- heparin binding [IDA]
- identical protein binding [IDA]
- lipid binding [IDA]
- lipid transporter activity [IDA]
- low-density lipoprotein particle receptor binding [IDA, IPI]
- metal chelating activity [IDA]
- phosphatidylcholine-sterol O-acyltransferase activator activity [IDA]
- phospholipid binding [IDA]
- protein binding [IPI]
- protein homodimerization activity [IPI]
- tau protein binding [IPI]
- very-low-density lipoprotein particle receptor binding [IDA, IPI]
Gene Ontology Cellular Component
- blood microparticle [IDA]
- chylomicron [IDA]
- cytoplasm [NAS, TAS]
- dendrite [NAS]
- early endosome [TAS]
- endocytic vesicle lumen [TAS]
- extracellular matrix [IDA]
- extracellular region [TAS]
- extracellular space [IDA]
- extracellular vesicular exosome [IDA]
- high-density lipoprotein particle [IDA]
- intermediate-density lipoprotein particle [IDA]
- low-density lipoprotein particle [IDA]
- membrane [IDA]
- neuronal cell body [NAS]
- nucleus [IDA]
- plasma membrane [TAS]
- very-low-density lipoprotein particle [IDA]
- vesicle [IDA]
Homo sapiens
PREY
LRP1
A2MR, APOER, APR, CD91, IGFBP3R, LRP, LRP1A, TGFBR5
low density lipoprotein receptor-related protein 1
GO Process (14)
GO Function (8)
GO Component (8)
Gene Ontology Biological Process
- aorta morphogenesis [ISS]
- apoptotic cell clearance [ISS]
- beta-amyloid clearance [TAS]
- lipoprotein transport [NAS]
- negative regulation of Wnt signaling pathway [ISS]
- negative regulation of platelet-derived growth factor receptor-beta signaling pathway [ISS]
- negative regulation of smooth muscle cell migration [ISS]
- phototransduction, visible light [TAS]
- positive regulation of cholesterol efflux [ISS]
- positive regulation of lipid transport [ISS]
- regulation of actin cytoskeleton organization [ISS]
- regulation of cholesterol transport [ISS]
- regulation of phospholipase A2 activity [ISS]
- retinoid metabolic process [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
The LDL-receptor-related protein, LRP, is an apolipoprotein E-binding protein.
The low-density-lipoprotein (LDL) receptor is a cell-surface protein that plays an important part in the metabolism of cholesterol by mediating the uptake of LDL from plasma into cells. Although LDL particles bind to the LDL receptor through their apolipoprotein B (apo B) and apolipoprotein E (apo E) moieties, other apo E-containing particles, like chylomicron remnants, are not dependent on the ... [more]
Nature Sep. 14, 1989; 341(6238);162-4 [Pubmed: 2779654]
Throughput
- Low Throughput
Curated By
- BioGRID