A genetic interaction is inferred when mutations or deletions in separate genes, each of which alone causes a minimal phenotype, result in lethality when combined in the same cell under a given condition.

Publication

A role for metaphase spindle elongation forces in correction of merotelic kinetochore attachments.

Choi SH, McCollum D

During mitosis, equal segregation of chromosomes depends on proper kinetochore-microtubule attachments. Merotelic kinetochore orientation, in which a single kinetochore binds microtubules from both spindle poles [1], isÂ a major cause of chromosome instability [2], which is commonly observed in solid tumors [3, 4]. Using the fission yeast Schizosaccharomyces pombe, we show that a proper force balance between kinesin motors on interpolar ... [more]

Curr. Biol. Feb. 07, 2012; 22(3);225-30 [Pubmed: 22264609]

Throughput

Low Throughput

Ontology Terms

phenotype: inviable (APO:0000112)

Related interactions

Interaction	Experimental Evidence Code	Dataset	Throughput	Score	Curated By	Notes
SWI6 BIR1	Synthetic Growth Defect Synthetic Growth Defect A genetic interaction is inferred when mutations in separate genes, each of which alone causes a minimal phenotype, result in a significant growth defect under a given condition when combined in the same cell.	Kawashima SA (2007)	Low	-	BioGRID	300518

Curated By

BioGRID

Interaction Summary

SWI6

Gene Ontology Biological Process

Gene Ontology Molecular Function

RNA binding [IDA]chromatin binding [IDA]methylated histone binding [IDA]nucleosomal histone binding [IPI]protein binding [IPI]

Gene Ontology Cellular Component

BIR1