PLXNB3
Gene Ontology Biological Process
- axon guidance [TAS]
- cell chemotaxis [IDA]
- negative regulation of GTPase activity [IMP]
- negative regulation of cell adhesion [IDA]
- negative regulation of cell migration [IMP]
- negative regulation of lamellipodium assembly [ISS]
- positive chemotaxis [IDA]
- positive regulation of endothelial cell proliferation [IMP]
- semaphorin-plexin signaling pathway [IDA]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
ARHGEF11
Gene Ontology Biological Process
- G-protein coupled receptor signaling pathway [IDA, TAS]
- Rho protein signal transduction [IDA]
- actin cytoskeleton organization [NAS]
- apoptotic signaling pathway [TAS]
- axon guidance [TAS]
- cellular component movement [NAS]
- cytokinesis [NAS]
- establishment of cell polarity [NAS]
- neurotrophin TRK receptor signaling pathway [TAS]
- positive regulation of Rho GTPase activity [TAS]
- positive regulation of apoptotic process [TAS]
- positive regulation of transcription, DNA-templated [IDA]
- regulation of cell growth [NAS]
- regulation of small GTPase mediated signal transduction [TAS]
- small GTPase mediated signal transduction [TAS]
- striated muscle contraction [NAS]
Gene Ontology Molecular Function
Two-hybrid
Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.
Publication
Protein-protein interactions between large proteins: two-hybrid screening using a functionally classified library composed of long cDNAs.
Large proteins have multiple domains that are potentially capable of binding many kinds of partners. It is conceivable, therefore, that such proteins could function as an intricate framework of assembly protein complexes. To comprehensively study protein-protein interactions between large KIAA proteins, we have constructed a library composed of 1087 KIAA cDNA clones based on prior functional classifications done in silico. ... [more]
Throughput
- Low Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| ARHGEF11 PLXNB3 | Affinity Capture-Western Affinity Capture-Western An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins. | Low | - | BioGRID | - | |
| ARHGEF11 PLXNB3 | Two-hybrid Two-hybrid Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation. | Low | - | BioGRID | - |
Curated By
- BioGRID