BAIT

TRA1

histone acetyltransferase TRA1, L000003945, YHR099W
Subunit of SAGA and NuA4 histone acetyltransferase complexes; interacts with acidic activators (e.g., Gal4p) which leads to transcription activation; similar to human TRRAP, which is a cofactor for c-Myc mediated oncogenic transformation
Kinome Project (Sc)
GO Process (3)
GO Function (1)
GO Component (5)

Gene Ontology Biological Process

Gene Ontology Molecular Function

Gene Ontology Cellular Component

Saccharomyces cerevisiae (S288c)
PREY

TTI2

YJR136C
Subunit of the ASTRA complex, involved in chromatin remodeling; telomere length regulator involved in the stability or biogenesis of PIKKs such as TORC1; similar to S. pombe Tti2p; may interact with Rsm23p; GFP-fusion protein localizes to the cytoplasm
GO Process (0)
GO Function (0)
GO Component (2)

Gene Ontology Cellular Component

Saccharomyces cerevisiae (S288c)

Synthetic Rescue

A genetic interaction is inferred when mutations or deletions of one gene rescues the lethality or growth defect of a strain mutated or deleted for another gene.

Publication

Genetic Evidence Links the ASTRA Protein Chaperone Component Tti2 to the SAGA Transcription Factor Tra1.

Genereaux J, Kvas S, Dobransky D, Karagiannis J, Gloor GB, Brandl CJ

Tra1 is a 3744-residue component of the Saccharomyces cerevisiae SAGA, NuA4 and ASTRA complexes. Tra1 contains essential C-terminal PI3K and FATC domains, but unlike other PIKK (phosphoinositide three-kinase-related kinase) family members, lacks kinase activity. To analyze functions of the FATC domain we selected for suppressors of tra1-F3744A, an allele that results in slow growth under numerous conditions of stress. Two ... [more]

Unknown Apr. 13, 2012; 0(0); [Pubmed: 22505622]

Throughput

  • Low Throughput

Ontology Terms

  • phenotype: heat sensitivity (APO:0000147)
  • phenotype: resistance to chemicals (APO:0000087)
  • phenotype: vegetative growth (APO:0000106)

Additional Notes

  • tti2-F328S and tti2-I336F rescue growth defect of tra1-F3744A at 37 degrees, and on plates containing ethanol, MMS, phleomycin, phosphate depletion, galactose, calcofluor white, pH 8, tunicamycin

Related interactions

InteractionExperimental Evidence CodeDatasetThroughputScoreCurated ByNotes
TRA1 TTI2
Phenotypic Suppression
Phenotypic Suppression

A genetic interaction is inferred when mutation or over expression of one gene results in suppression of any phenotype (other than lethality/growth defect) associated with mutation or over expression of another gene.

Low-BioGRID
656353
TRA1 TTI2
Synthetic Lethality
Synthetic Lethality

A genetic interaction is inferred when mutations or deletions in separate genes, each of which alone causes a minimal phenotype, result in lethality when combined in the same cell under a given condition.

Low-BioGRID
2394221

Curated By

  • BioGRID