NIPBL
Gene Ontology Biological Process
- brain development [IMP]
- cellular protein localization [IMP]
- cellular response to DNA damage stimulus [IMP]
- cellular response to X-ray [IMP]
- cognition [IMP]
- developmental growth [IMP]
- ear morphogenesis [IMP]
- embryonic digestive tract morphogenesis [IMP]
- embryonic forelimb morphogenesis [IMP]
- external genitalia morphogenesis [IMP]
- eye morphogenesis [IMP]
- face morphogenesis [IMP]
- forelimb morphogenesis [IMP]
- gall bladder development [IMP]
- heart morphogenesis [IMP]
- maintenance of mitotic sister chromatid cohesion [IMP]
- metanephros development [NAS]
- mitotic cell cycle [TAS]
- mitotic sister chromatid cohesion [IMP]
- negative regulation of transcription from RNA polymerase II promoter [IDA]
- negative regulation of transcription, DNA-templated [IDA]
- outflow tract morphogenesis [IMP]
- positive regulation of histone deacetylation [IDA]
- regulation of developmental growth [IMP]
- regulation of embryonic development [IMP]
- regulation of hair cycle [IMP]
- sensory perception of sound [IMP]
- uterus morphogenesis [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
SMC3
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
Mediator and cohesin connect gene expression and chromatin architecture.
Transcription factors control cell-specific gene expression programs through interactions with diverse coactivators and the transcription apparatus. Gene activation may involve DNA loop formation between enhancer-bound transcription factors and the transcription apparatus at the core promoter, but this process is not well understood. Here we report that mediator and cohesin physically and functionally connect the enhancers and core promoters of active ... [more]
Throughput
- Low Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| SMC3 NIPBL | Affinity Capture-MS Affinity Capture-MS An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods. | High | - | BioGRID | - | |
| NIPBL SMC3 | Affinity Capture-Western Affinity Capture-Western An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins. | Low | - | BioGRID | - | |
| NIPBL SMC3 | Affinity Capture-Western Affinity Capture-Western An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins. | Low | - | BioGRID | - |
Curated By
- BioGRID