BAIT
ELAVL1
ELAV1, HUR, Hua, MelG
ELAV like RNA binding protein 1
GO Process (8)
GO Function (9)
GO Component (5)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Homo sapiens
PREY
PRKAG2
AAKG, AAKG2, CMH6, H91620p, WPWS
protein kinase, AMP-activated, gamma 2 non-catalytic subunit
GO Process (20)
GO Function (7)
GO Component (4)
Gene Ontology Biological Process
- ATP biosynthetic process [TAS]
- carnitine shuttle [TAS]
- cell cycle arrest [TAS]
- cellular lipid metabolic process [TAS]
- energy reserve metabolic process [TAS]
- glycogen metabolic process [IMP]
- insulin receptor signaling pathway [TAS]
- intracellular signal transduction [IMP]
- membrane organization [TAS]
- negative regulation of protein kinase activity [IDA]
- negative regulation of protein serine/threonine kinase activity [IDA]
- positive regulation of peptidyl-threonine phosphorylation [IMP]
- positive regulation of protein kinase activity [IMP]
- regulation of fatty acid biosynthetic process [TAS]
- regulation of fatty acid metabolic process [IMP]
- regulation of fatty acid oxidation [TAS]
- regulation of glucose import [TAS]
- regulation of glycolytic process [IMP]
- small molecule metabolic process [TAS]
- sterol biosynthetic process [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Affinity Capture-RNA
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and associated RNA species identified by Northern blot, RT-PCR, affinity labeling, sequencing, or microarray analysis.
Publication
Ubiquitin-mediated proteolysis of HuR by heat shock.
The RNA-binding protein HuR regulates the stability and translation of numerous mRNAs encoding stress-response and proliferative proteins. Although its post-transcriptional influence has been linked primarily to its cytoplasmic translocation, here we report that moderate heat shock (HS) potently reduces HuR levels, thereby altering the expression of HuR target mRNAs. HS did not change HuR mRNA levels or de novo translation, ... [more]
EMBO J. May. 06, 2009; 28(9);1271-82 [Pubmed: 19322201]
Throughput
- High Throughput
Ontology Terms
- hela cell (BTO:0000567) [cervical adenocarcinoma (DOID:3702)]
Curated By
- BioGRID