ARRB2
Gene Ontology Biological Process
- G-protein coupled receptor internalization [IDA, IMP]
- Notch signaling pathway [TAS]
- blood coagulation [TAS]
- cell chemotaxis [IMP]
- desensitization of G-protein coupled receptor protein signaling pathway by arrestin [IMP]
- negative regulation of NF-kappaB transcription factor activity [IDA]
- negative regulation of natural killer cell mediated cytotoxicity [IMP]
- negative regulation of protein ubiquitination [IDA]
- platelet activation [TAS]
- positive regulation of ERK1 and ERK2 cascade [IDA, IMP]
- positive regulation of protein ubiquitination [IGI]
- positive regulation of receptor internalization [IMP]
- proteasome-mediated ubiquitin-dependent protein catabolic process [IMP]
- protein ubiquitination [IMP]
- receptor internalization [IDA]
- regulation of androgen receptor signaling pathway [IDA]
- transcription from RNA polymerase II promoter [IDA]
- transforming growth factor beta receptor signaling pathway [IDA]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
PDE4D
Gene Ontology Biological Process
- T cell receptor signaling pathway [IMP]
- adrenergic receptor signaling pathway [ISS]
- adrenergic receptor signaling pathway involved in positive regulation of heart rate [IC]
- cAMP catabolic process [IDA, IGI, IMP]
- cAMP-mediated signaling [NAS]
- cellular response to cAMP [IDA]
- cellular response to epinephrine stimulus [IDA]
- establishment of endothelial barrier [ISS]
- negative regulation of heart contraction [ISS]
- negative regulation of peptidyl-serine phosphorylation [ISS]
- negative regulation of relaxation of cardiac muscle [ISS]
- positive regulation of interferon-gamma production [IMP]
- positive regulation of interleukin-2 production [IMP]
- positive regulation of interleukin-5 production [IMP]
- regulation of cardiac muscle cell contraction [ISS]
- regulation of cell communication by electrical coupling involved in cardiac conduction [IC]
- regulation of heart rate [ISS]
- regulation of receptor activity [ISS]
- regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum [ISS]
- regulation of ryanodine-sensitive calcium-release channel activity [ISS]
Gene Ontology Molecular Function- 3',5'-cyclic-AMP phosphodiesterase activity [IDA, IGI]
- 3',5'-cyclic-nucleotide phosphodiesterase activity [NAS]
- ATPase binding [IPI]
- beta-2 adrenergic receptor binding [ISS]
- cAMP binding [IDA]
- drug binding [IPI]
- enzyme binding [ISS]
- ion channel binding [IPI, ISS]
- protein binding [IPI]
- scaffold protein binding [IPI]
- ubiquitin protein ligase binding [IPI]
- 3',5'-cyclic-AMP phosphodiesterase activity [IDA, IGI]
- 3',5'-cyclic-nucleotide phosphodiesterase activity [NAS]
- ATPase binding [IPI]
- beta-2 adrenergic receptor binding [ISS]
- cAMP binding [IDA]
- drug binding [IPI]
- enzyme binding [ISS]
- ion channel binding [IPI, ISS]
- protein binding [IPI]
- scaffold protein binding [IPI]
- ubiquitin protein ligase binding [IPI]
Gene Ontology Cellular Component
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Functional specialization of beta-arrestin interactions revealed by proteomic analysis.
Beta-arrestins are cytosolic proteins that form complexes with seven-transmembrane receptors after agonist stimulation and phosphorylation by the G protein-coupled receptor kinases. They play an essential role in receptor desensitization and endocytosis, and they also serve as receptor-regulated signaling scaffolds and adaptors. Moreover, in the past decade, a growing list of protein-protein interactions of beta-arrestins pertinent to these functions has been ... [more]
Throughput
- High Throughput
Ontology Terms
- cell line: hek-293 cell (BTO:0000007)
Additional Notes
- exogenous expression of bait
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| PDE4D ARRB2 | Affinity Capture-Western Affinity Capture-Western An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins. | Low | - | BioGRID | - | |
| PDE4D ARRB2 | Two-hybrid Two-hybrid Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation. | Low | - | BioGRID | - |
Curated By
- BioGRID