BAIT

DOT1L

DOT1, KMT4
DOT1-like histone H3K79 methyltransferase
Homo sapiens
PREY

HIST3H3

H3.4, H3/g, H3FT, H3t
histone cluster 3, H3
GO Process (1)
GO Function (1)
GO Component (3)

Gene Ontology Biological Process

Gene Ontology Molecular Function

Gene Ontology Cellular Component

Homo sapiens

Biochemical Activity (Methylation)

An interaction is inferred from the biochemical effect of one protein upon another, for example, GTP-GDP exchange activity or phosphorylation of a substrate by a kinase. The bait protein executes the activity on the substrate hit protein. A Modification value is recorded for interactions of this type with the possible values Phosphorylation, Ubiquitination, Sumoylation, Dephosphorylation, Methylation, Prenylation, Acetylation, Deubiquitination, Proteolytic Processing, Glucosylation, Nedd(Rub1)ylation, Deacetylation, No Modification, Demethylation.

Publication

Histone Monoubiquitylation Position Determines Specificity and Direction of Enzymatic Crosstalk with Histone Methyltransferases Dot1L and PRC2.

Whitcomb SJ, Fierz B, McGinty RK, Holt M, Ito T, Muir TW, Allis CD

It is well established that chromatin is a destination for signal transduction affecting many DNA-templated processes. Histone proteins in particular are extensively post- translationally modified. We are interested in how the complex repertoire of histone modifications is coordinately regulated to generate meaningful combinations of ″marks″ at physiologically relevant genomic locations. One important mechanism is ″crosstalk″ between pre-existing histone post-translational modifications ... [more]

Unknown May. 22, 2012; 0(0); [Pubmed: 22619169]

Throughput

  • Low Throughput

Additional Notes

  • figure 2B.
  • figure 2C. effect of the substrate complex state on the methylation of H3.

Curated By

  • BioGRID