BAIT

KDM3B

5qNCA, C5orf7, JMJD1B, NET22
lysine (K)-specific demethylase 3B
GO Process (0)
GO Function (0)
GO Component (0)
Homo sapiens
PREY

HIST3H3

H3.4, H3/g, H3FT, H3t
histone cluster 3, H3
GO Process (1)
GO Function (1)
GO Component (3)

Gene Ontology Biological Process

Gene Ontology Molecular Function

Gene Ontology Cellular Component

Homo sapiens

Biochemical Activity (Demethylation)

An interaction is inferred from the biochemical effect of one protein upon another, for example, GTP-GDP exchange activity or phosphorylation of a substrate by a kinase. The bait protein executes the activity on the substrate hit protein. A Modification value is recorded for interactions of this type with the possible values Phosphorylation, Ubiquitination, Sumoylation, Dephosphorylation, Methylation, Prenylation, Acetylation, Deubiquitination, Proteolytic Processing, Glucosylation, Nedd(Rub1)ylation, Deacetylation, No Modification, Demethylation.

Publication

KDM3B is the H3K9 demethylase involved in transcriptional activation of lmo2 in leukemia.

Kim JY, Kim KB, Eom GH, Choe NW, Kee HJ, Son HJ, Oh ST, Kim DW, Pak JH, Baek HJ, Kook H, Hahn Y, Kook H, Chakravarti D, Seo SB

Histone lysine methylation and demethylation are considered critical steps in transcriptional regulation. In this report, we performed ChIP-chip analysis to examine the genome-wide occupancy of H3K9-me2 during all-trans retinoid acid (ATRA)-induced differentiation of HL-60 promyelocytic leukemia cells. Using this approach, we found that KDM3B, which contains a JmjC domain, was down-regulated during differentiation through the recruitment of a corepressor complex. ... [more]

Unknown May. 21, 2012; 0(0); [Pubmed: 22615488]

Throughput

  • Low Throughput

Additional Notes

  • figure 2D.
  • figure 2G.

Curated By

  • BioGRID