BAIT

LIN28A

CSDD1, LIN-28, LIN28, ZCCHC1, lin-28A
lin-28 homolog A (C. elegans)
GO Process (4)
GO Function (2)
GO Component (4)

Gene Ontology Biological Process

Gene Ontology Molecular Function

Gene Ontology Cellular Component

Homo sapiens
PREY

DOT1L

DOT1, KMT4
DOT1-like histone H3K79 methyltransferase
Homo sapiens

Phenotypic Suppression

A genetic interaction is inferred when mutation or over expression of one gene results in suppression of any phenotype (other than lethality/growth defect) associated with mutation or over expression of another gene.

Publication

Chromatin-modifying enzymes as modulators of reprogramming.

Onder TT, Kara N, Cherry A, Sinha AU, Zhu N, Bernt KM, Cahan P, Marcarci BO, Unternaehrer J, Gupta PB, Lander ES, Armstrong SA, Daley GQ

Generation of induced pluripotent stem cells (iPSCs) by somatic cell reprogramming involves global epigenetic remodelling. Whereas several proteins are known to regulate chromatin marks associated with the distinct epigenetic states of cells before and after reprogramming, the role of specific chromatin-modifying enzymes in reprogramming remains to be determined. To address how chromatin-modifying proteins influence reprogramming, we used short hairpin RNAs ... [more]

Nature Mar. 29, 2012; 483(7391);598-602 [Pubmed: 22388813]

Throughput

  • Low Throughput

Additional Notes

  • figure 3. NANOG and LIN28 are required for enhancement of reprogramming by DOT1L inhibition

Curated By

  • BioGRID