ACP2
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
FIM1
Gene Ontology Biological Process
- actin cortical patch localization [IMP]
- actin crosslink formation [IPI]
- actin cytoskeleton organization [IGI]
- actin filament bundle assembly [IMP]
- ascospore formation [IMP]
- establishment or maintenance of cell polarity regulating cell shape [IMP]
- mitotic actomyosin contractile ring assembly [IMP]
- mitotic cytokinesis [IGI]
- negative regulation of actin filament depolymerization [IMP]
- regulation of cell shape [IGI]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Synthetic Lethality
A genetic interaction is inferred when mutations or deletions in separate genes, each of which alone causes a minimal phenotype, result in lethality when combined in the same cell under a given condition.
Publication
Profilin-mediated competition between capping protein and formin Cdc12p during cytokinesis in fission yeast.
Fission yeast capping protein SpCP is a heterodimer of two subunits (Acp1p and Acp2p) that binds actin filament barbed ends. Neither acp1 nor acp2 is required for viability, but cells lacking either or both subunits have cytokinesis defects under stressful conditions, including elevated temperature, osmotic stress, or in combination with numerous mild mutations in genes important for cytokinesis. Defects arise ... [more]
Throughput
- Low Throughput
Ontology Terms
- phenotype: inviable (APO:0000112)
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| ACP2 FIM1 | Synthetic Growth Defect Synthetic Growth Defect A genetic interaction is inferred when mutations in separate genes, each of which alone causes a minimal phenotype, result in a significant growth defect under a given condition when combined in the same cell. | Low | - | BioGRID | 448964 |
Curated By
- BioGRID