BAIT
SKA2
FAM33A
spindle and kinetochore associated complex subunit 2
GO Process (5)
GO Function (2)
GO Component (3)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
SPC24
SPBC24
SPC24, NDC80 kinetochore complex component
GO Process (1)
GO Function (1)
GO Component (4)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Homo sapiens
Two-hybrid
Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.
Publication
Aurora B controls kinetochore-microtubule attachments by inhibiting Ska complex-KMN network interaction.
The KMN network (named according to the acronym for KNL1, Mis12, and Ndc80) and the more recently identified Ska complex (Ska1-3) have been shown to mediate kinetochore (KT)-microtubule (MT) attachments. How these two complexes cooperate to achieve stable end-on attachments remains unknown. In this paper, we show that Aurora B negatively regulates the localization of the Ska complex to KTs ... [more]
J. Cell Biol. Mar. 05, 2012; 196(5);563-71 [Pubmed: 22371557]
Throughput
- Low Throughput
Additional Notes
- figure S2C.
Curated By
- BioGRID