GZMA
Gene Ontology Biological Process
- apoptotic process [TAS]
- immune response [TAS]
- negative regulation of DNA binding [IDA]
- negative regulation of endodeoxyribonuclease activity [IDA]
- negative regulation of oxidoreductase activity [IDA]
- positive regulation of apoptotic process [IDA]
- proteolysis involved in cellular protein catabolic process [IDA]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
NDUFS3
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Biochemical Activity (Proteolytic Processing)
An interaction is inferred from the biochemical effect of one protein upon another, for example, GTP-GDP exchange activity or phosphorylation of a substrate by a kinase. The bait protein executes the activity on the substrate hit protein. A Modification value is recorded for interactions of this type with the possible values Phosphorylation, Ubiquitination, Sumoylation, Dephosphorylation, Methylation, Prenylation, Acetylation, Deubiquitination, Proteolytic Processing, Glucosylation, Nedd(Rub1)ylation, Deacetylation, No Modification, Demethylation.
Publication
Granzyme A cleaves a mitochondrial complex I protein to initiate caspase-independent cell death.
The killer lymphocyte protease granzyme A (GzmA) triggers caspase-independent target cell death with morphological features of apoptosis. We previously showed that GzmA acts directly on mitochondria to generate reactive oxygen species (ROS) and disrupt the transmembrane potential (DeltaPsi(m)) but does not permeabilize the mitochondrial outer membrane. Mitochondrial damage is critical to GzmA-induced cell death since cells treated with superoxide scavengers ... [more]
Throughput
- Low Throughput
Curated By
- BioGRID