BAIT
CBLB
AI429560, AI851073, Cbl-b
Casitas B-lineage lymphoma b
GO Process (8)
GO Function (2)
GO Component (4)
Gene Ontology Biological Process
- T cell activation [IMP]
- immune response [IMP]
- intracellular signal transduction [IMP]
- negative regulation of T cell receptor signaling pathway [IMP]
- negative regulation of alpha-beta T cell proliferation [IMP]
- positive regulation of T cell anergy [IMP]
- positive regulation of protein catabolic process [IMP]
- signal transduction [ISO]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
PREY
TLR4
Lps, Ly87, Ran/M1, Rasl2-8, RP24-209H15.1
toll-like receptor 4
GO Process (71)
GO Function (5)
GO Component (8)
Gene Ontology Biological Process
- B cell proliferation involved in immune response [IMP]
- I-kappaB phosphorylation [IMP, ISO]
- activation of MAPK activity [IMP]
- activation of NF-kappaB-inducing kinase activity [NAS]
- activation of innate immune response [IMP]
- cellular response to lipopolysaccharide [IDA, IMP]
- cellular response to lipoteichoic acid [IMP]
- defense response to Gram-negative bacterium [IMP]
- detection of lipopolysaccharide [ISO, TAS]
- innate immune response [TAS]
- innate immune response-activating signal transduction [ISO]
- interferon-gamma production [IGI]
- intestinal epithelial structure maintenance [IMP]
- leukotriene metabolic process [ISO]
- lipopolysaccharide-mediated signaling pathway [IDA, IGI, ISO]
- macrophage activation [ISO, ISS]
- mast cell activation [NAS]
- microglial cell activation [ISO]
- negative regulation of ERK1 and ERK2 cascade [IMP]
- negative regulation of interferon-gamma production [IMP]
- negative regulation of interleukin-17 production [IMP]
- negative regulation of interleukin-23 production [IMP]
- negative regulation of interleukin-6 production [IMP]
- negative regulation of tumor necrosis factor production [IMP]
- nitric oxide production involved in inflammatory response [IMP]
- positive regulation of B cell proliferation [IMP]
- positive regulation of DNA binding [ISO]
- positive regulation of ERK1 and ERK2 cascade [IDA]
- positive regulation of I-kappaB kinase/NF-kappaB signaling [IDA]
- positive regulation of JNK cascade [IDA, IGI]
- positive regulation of MHC class II biosynthetic process [IMP]
- positive regulation of NF-kappaB import into nucleus [ISO]
- positive regulation of NF-kappaB transcription factor activity [ISO]
- positive regulation of apoptotic process [ISO]
- positive regulation of chemokine production [IDA, ISO]
- positive regulation of inflammatory response [ISO]
- positive regulation of interferon-alpha production [IDA]
- positive regulation of interferon-beta biosynthetic process [IMP]
- positive regulation of interferon-beta production [IDA]
- positive regulation of interferon-gamma production [IMP]
- positive regulation of interleukin-1 biosynthetic process [NAS]
- positive regulation of interleukin-1 production [IDA]
- positive regulation of interleukin-10 production [IDA]
- positive regulation of interleukin-12 biosynthetic process [ISO]
- positive regulation of interleukin-12 production [IDA]
- positive regulation of interleukin-13 biosynthetic process [NAS]
- positive regulation of interleukin-6 biosynthetic process [NAS]
- positive regulation of interleukin-6 production [IDA, IMP, ISO, NAS]
- positive regulation of interleukin-8 biosynthetic process [ISO]
- positive regulation of interleukin-8 production [ISO]
- positive regulation of lymphocyte proliferation [IMP]
- positive regulation of macrophage cytokine production [IMP]
- positive regulation of nitric oxide biosynthetic process [IMP]
- positive regulation of nitric-oxide synthase biosynthetic process [IDA]
- positive regulation of nucleotide-binding oligomerization domain containing 1 signaling pathway [IDA]
- positive regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway [IDA]
- positive regulation of peptidyl-tyrosine phosphorylation [ISO]
- positive regulation of platelet activation [IMP]
- positive regulation of sequence-specific DNA binding transcription factor activity [ISO]
- positive regulation of stress-activated MAPK cascade [IDA]
- positive regulation of transcription from RNA polymerase II promoter [IDA]
- positive regulation of tumor necrosis factor biosynthetic process [ISO]
- positive regulation of tumor necrosis factor production [IDA, IMP]
- regulation of inflammatory response [IMP]
- regulation of sensory perception of pain [ISO]
- response to bacterium [IMP]
- response to ethanol [ISO]
- response to fatty acid [ISO]
- response to lipopolysaccharide [IGI, IMP, ISO]
- response to oxidative stress [ISO]
- toll-like receptor signaling pathway [ISO]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
E3 ubiquitin ligase Cblb regulates the acute inflammatory response underlying lung injury.
The E3 ubiquitin ligase Cblb has a crucial role in the prevention of chronic inflammation and autoimmunity. Here we show that Cblb also has an unexpected function in acute lung inflammation. Cblb attenuates the sequestration of inflammatory cells in the lungs after administration of lipopolysaccharide (LPS). In a model of polymicrobial sepsis in which acute lung inflammation depends on the ... [more]
Nat. Med. Aug. 01, 2007; 13(8);920-6 [Pubmed: 17618294]
Throughput
- Low Throughput
Curated By
- BioGRID