PER1
Gene Ontology Biological Process
- circadian regulation of gene expression [IDA, IMP, ISO]
- circadian regulation of translation [IMP]
- circadian rhythm [ISO, TAS]
- entrainment of circadian clock by photoperiod [IMP]
- histone H3 acetylation [IDA, ISO]
- histone H3 deacetylation [IMP]
- histone H4 acetylation [ISO]
- negative regulation of I-kappaB kinase/NF-kappaB signaling [ISO]
- negative regulation of JNK cascade [ISO]
- negative regulation of glucocorticoid receptor signaling pathway [IMP]
- negative regulation of transcription from RNA polymerase II promoter [IDA, IMP]
- negative regulation of transcription, DNA-templated [IDA]
- positive regulation of transcription from RNA polymerase II promoter [IMP]
- posttranscriptional regulation of gene expression [IMP]
- regulation of circadian rhythm [IMP]
- regulation of cytokine production involved in inflammatory response [ISO]
- regulation of hair cycle [ISO]
- regulation of p38MAPK cascade [ISO]
- regulation of sodium ion transport [IMP]
- response to cAMP [IDA]
Gene Ontology Molecular Function- E-box binding [ISO]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding [ISO]
- chromatin DNA binding [IDA]
- kinase binding [IPI, ISO]
- protein binding [IPI]
- transcription factor binding [IPI]
- transcription factor binding transcription factor activity [IDA]
- transcription regulatory region sequence-specific DNA binding [IDA]
- ubiquitin protein ligase binding [ISO]
- E-box binding [ISO]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding [ISO]
- chromatin DNA binding [IDA]
- kinase binding [IPI, ISO]
- protein binding [IPI]
- transcription factor binding [IPI]
- transcription factor binding transcription factor activity [IDA]
- transcription regulatory region sequence-specific DNA binding [IDA]
- ubiquitin protein ligase binding [ISO]
CSNK1E
Gene Ontology Biological Process
- cellular protein localization [IDA]
- circadian regulation of gene expression [IMP]
- circadian rhythm [TAS]
- endocytosis [IBA]
- negative regulation of Wnt signaling pathway [IGI]
- peptidyl-serine phosphorylation [IBA]
- positive regulation of canonical Wnt signaling pathway [IGI]
- positive regulation of proteasomal ubiquitin-dependent protein catabolic process [IMP]
- protein phosphorylation [IDA, IMP, ISO]
- regulation of cell shape [IBA]
- regulation of circadian rhythm [IMP]
Gene Ontology Molecular Function
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
A molecular mechanism for circadian clock negative feedback.
Circadian rhythms in mammals are generated by a feedback loop in which the three PERIOD (PER) proteins, acting in a large complex, inhibit the transcriptional activity of the CLOCK-BMAL1 dimer, which represses their own expression. Although fundamental, the mechanism of negative feedback in the mammalian clock, or any eukaryotic clock, is unknown. We analyzed protein constituents of PER complexes purified ... [more]
Throughput
- Low Throughput
Additional Notes
- figure S1.
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| PER1 CSNK1E | Affinity Capture-Western Affinity Capture-Western An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins. | Low | - | BioGRID | 676345 | |
| PER1 CSNK1E | Affinity Capture-Western Affinity Capture-Western An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins. | Low | - | BioGRID | - | |
| CSNK1E PER1 | Affinity Capture-Western Affinity Capture-Western An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins. | Low | - | BioGRID | - |
Curated By
- BioGRID