RES1
Gene Ontology Biological Process
- positive regulation of G1/S transition of mitotic cell cycle [IMP]
- positive regulation of transcription from RNA polymerase II promoter [IMP]
- positive regulation of transcription involved in G1/S transition of mitotic cell cycle [IC, IMP]
- regulation of transcription involved in G1/S transition of mitotic cell cycle [IMP]
- transcription from RNA polymerase II promoter [IMP]
- traversing start control point of mitotic cell cycle [IMP]
Gene Ontology Molecular Function- RNA polymerase II core promoter proximal region sequence-specific DNA binding [IDA]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [IMP]
- RNA polymerase II core promoter sequence-specific DNA binding transcription factor activity [IMP]
- chromatin binding [IDA]
- protein binding [IPI]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding [IDA]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [IMP]
- RNA polymerase II core promoter sequence-specific DNA binding transcription factor activity [IMP]
- chromatin binding [IDA]
- protein binding [IPI]
Gene Ontology Cellular Component
RES2
Gene Ontology Biological Process
- positive regulation of transcription from RNA polymerase II promoter [IMP]
- positive regulation of transcription involved in G1/S transition of mitotic cell cycle [IMP]
- regulation of meiotic cell cycle [IMP]
- regulation of transcription, DNA-templated [IDA]
- transcription from RNA polymerase II promoter [IMP]
Gene Ontology Molecular Function
Synthetic Rescue
A genetic interaction is inferred when mutations or deletions of one gene rescues the lethality or growth defect of a strain mutated or deleted for another gene.
Publication
Domains determining the functional distinction of the fission yeast cell cycle "start" molecules Res1 and Res2.
In Schizosaccharomyces pombe the "start" of the cell cycle is regulated by two parallel, functionally overlapping complexes composed of Res1-Cdc10 and Res2-Cdc10. Res1 and Res2 are structurally very homologous and are required for the start of the mitotic and meiotic cycle, respectively. We have addressed the question which parts of the proteins are essential for function and determine the functional ... [more]
Throughput
- Low Throughput
Ontology Terms
- phenotype: meiosis (APO:0000039)
Additional Notes
- internally truncated forms of Res2 lacking the centrally located ankyrin repeats and adjacent sequences can partially suppress the meiotic defect in res1 mutant cells
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| RES1 RES2 | Dosage Rescue Dosage Rescue A genetic interaction is inferred when over expression or increased dosage of one gene rescues the lethality or growth defect of a strain that is mutated or deleted for another gene. | High | - | PomBase | - | |
| RES1 RES2 | Dosage Rescue Dosage Rescue A genetic interaction is inferred when over expression or increased dosage of one gene rescues the lethality or growth defect of a strain that is mutated or deleted for another gene. | Low | - | BioGRID | 247681 | |
| RES1 RES2 | Dosage Rescue Dosage Rescue A genetic interaction is inferred when over expression or increased dosage of one gene rescues the lethality or growth defect of a strain that is mutated or deleted for another gene. | Low | - | BioGRID | 246722 | |
| RES1 RES2 | Reconstituted Complex Reconstituted Complex An interaction is detected between purified proteins in vitro. | Low | - | BioGRID | - | |
| RES1 RES2 | Reconstituted Complex Reconstituted Complex An interaction is detected between purified proteins in vitro. | Low | - | BioGRID | - | |
| RES1 RES2 | Synthetic Lethality Synthetic Lethality A genetic interaction is inferred when mutations or deletions in separate genes, each of which alone causes a minimal phenotype, result in lethality when combined in the same cell under a given condition. | Low | - | BioGRID | 798213 | |
| RES2 RES1 | Synthetic Rescue Synthetic Rescue A genetic interaction is inferred when mutations or deletions of one gene rescues the lethality or growth defect of a strain mutated or deleted for another gene. | Low | - | BioGRID | 246450 |
Curated By
- BioGRID