BAIT
TOLLIP
IL-1RAcPIP
toll interacting protein
GO Process (8)
GO Function (4)
GO Component (5)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
CAV1
BSCL3, CGL3, LCCNS, MSTP085, PPH3, VIP21
caveolin 1, caveolae protein, 22kDa
GO Process (65)
GO Function (13)
GO Component (15)
Gene Ontology Biological Process
- T cell costimulation [IDA]
- apoptotic signaling pathway [IMP]
- blood coagulation [TAS]
- calcium ion homeostasis [ISS]
- calcium ion transport [ISS]
- caveola assembly [IGI, IMP]
- caveolin-mediated endocytosis [IDA]
- cellular calcium ion homeostasis [ISS]
- cellular response to hyperoxia [IMP]
- cellular response to starvation [IEP]
- cholesterol homeostasis [ISS, TAS]
- cholesterol transport [TAS]
- cytosolic calcium ion homeostasis [IDA]
- inactivation of MAPK activity [ISS]
- leukocyte migration [TAS]
- lipid storage [ISS]
- maintenance of protein location in cell [ISS]
- mammary gland development [ISS]
- mammary gland involution [ISS]
- membrane depolarization [ISS]
- negative regulation of BMP signaling pathway [IDA]
- negative regulation of JAK-STAT cascade [ISS]
- negative regulation of MAPK cascade [ISS]
- negative regulation of anoikis [IMP]
- negative regulation of canonical Wnt signaling pathway [ISS]
- negative regulation of endothelial cell proliferation [ISS]
- negative regulation of epithelial cell differentiation [ISS]
- negative regulation of nitric oxide biosynthetic process [ISS]
- negative regulation of peptidyl-serine phosphorylation [IDA]
- negative regulation of peptidyl-tyrosine autophosphorylation [IMP]
- negative regulation of pinocytosis [IMP]
- negative regulation of potassium ion transmembrane transport [IMP]
- negative regulation of protein binding [IDA]
- negative regulation of protein tyrosine kinase activity [IMP]
- negative regulation of protein ubiquitination [IMP]
- negative regulation of transcription from RNA polymerase II promoter [ISS]
- nitric oxide homeostasis [ISS]
- nitric oxide metabolic process [TAS]
- positive regulation of calcium ion transport into cytosol [ISS]
- positive regulation of canonical Wnt signaling pathway [IMP]
- positive regulation of extrinsic apoptotic signaling pathway [IMP]
- positive regulation of intrinsic apoptotic signaling pathway [IMP]
- positive regulation of metalloenzyme activity [ISS]
- positive regulation of peptidyl-serine phosphorylation [IDA]
- positive regulation of vasoconstriction [ISS]
- protein homooligomerization [ISS]
- protein localization [ISS]
- receptor internalization involved in canonical Wnt signaling pathway [IMP]
- regulation of blood coagulation [IMP]
- regulation of cardiac muscle cell action potential involved in regulation of contraction [IC]
- regulation of fatty acid metabolic process [ISS]
- regulation of inward rectifier potassium channel activity [IMP]
- regulation of membrane repolarization during action potential [IMP]
- regulation of nitric-oxide synthase activity [TAS]
- regulation of peptidase activity [ISS]
- regulation of smooth muscle contraction [ISS]
- response to calcium ion [ISS]
- response to estrogen [IDA]
- response to hypoxia [ISS]
- response to progesterone [IDA]
- skeletal muscle tissue development [ISS]
- small molecule metabolic process [TAS]
- triglyceride metabolic process [ISS]
- vasculogenesis [ISS]
- vesicle organization [IDA]
Gene Ontology Molecular Function- cholesterol binding [TAS]
- enzyme binding [IPI]
- identical protein binding [IPI]
- inward rectifier potassium channel inhibitor activity [IDA]
- ion channel binding [IPI]
- nitric-oxide synthase binding [IPI]
- patched binding [NAS]
- peptidase activator activity [ISS]
- protein binding [IPI]
- protein complex scaffold [TAS]
- protein kinase binding [IPI]
- receptor binding [IPI]
- structural molecule activity [IDA]
- cholesterol binding [TAS]
- enzyme binding [IPI]
- identical protein binding [IPI]
- inward rectifier potassium channel inhibitor activity [IDA]
- ion channel binding [IPI]
- nitric-oxide synthase binding [IPI]
- patched binding [NAS]
- peptidase activator activity [ISS]
- protein binding [IPI]
- protein complex scaffold [TAS]
- protein kinase binding [IPI]
- receptor binding [IPI]
- structural molecule activity [IDA]
Gene Ontology Cellular Component
- Golgi membrane [IDA, TAS]
- apical plasma membrane [IDA]
- basolateral plasma membrane [IDA]
- caveola [IDA, NAS]
- cytoplasmic vesicle [IDA]
- endocytic vesicle membrane [TAS]
- endoplasmic reticulum [IDA]
- endosome [IDA]
- focal adhesion [IDA]
- intracellular [IDA]
- lipid particle [TAS]
- membrane raft [IDA]
- perinuclear region of cytoplasm [IDA, ISS]
- plasma membrane [IDA, TAS]
- protein complex [IDA]
Homo sapiens
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
CD26 mediates dissociation of Tollip and IRAK-1 from caveolin-1 and induces upregulation of CD86 on antigen-presenting cells.
CD26 is a T-cell costimulatory molecule with dipeptidyl peptidase IV enzyme activity in its extracellular region. We have previously reported that the addition of recombinant soluble CD26 resulted in enhanced proliferation of human T lymphocytes induced by the recall antigen tetanus toxoid (TT) via upregulation of CD86 on monocytes and that caveolin-1 was a binding protein of CD26, and the ... [more]
Mol. Cell. Biol. Sep. 01, 2005; 25(17);7743-57 [Pubmed: 16107720]
Throughput
- Low Throughput
Ontology Terms
- monocyte (CL:0000576)
Curated By
- BioGRID