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BAIT

SPP1

BNSP, BSPI, ETA-1, OPN, PSEC0156

secreted phosphoprotein 1

GO Process (5)

GO Function (1)

GO Component (3)

Gene Ontology Biological Process

decidualization [TAS]

embryo implantation [TAS]

extracellular matrix disassembly [TAS]

extracellular matrix organization [TAS]

response to vitamin D [IDA]

Gene Ontology Molecular Function

protein binding [IPI]

Gene Ontology Cellular Component

extracellular region [TAS]

extracellular space [IDA]

extracellular vesicular exosome [IDA]

CRISPR Database HGNC Alliance of Genome Resources OMIM VEGA Entrez Gene RefSeq UniprotKB Ensembl HPRD

Homo sapiens

PREY

EEF1A1

CCS-3, CCS3, EE1A1, EEF-1, EEF1A, EF-Tu, EF1A, GRAF-1EF, HNGC:16303, LENG7, PTI1, eEF1A-1, RP11-505P4.2

eukaryotic translation elongation factor 1 alpha 1

GO Process (5)

GO Function (5)

GO Component (8)

Gene Ontology Biological Process

cellular protein metabolic process [TAS]

cellular response to epidermal growth factor stimulus [IDA]

gene expression [TAS]

translation [TAS]

translational elongation [TAS]

Gene Ontology Molecular Function

GTP binding [TAS]
poly(A) RNA binding [IDA]
protein binding [IPI]
protein kinase binding [IPI]
translation elongation factor activity [TAS]

Gene Ontology Cellular Component

cytoplasm [IDA, ISS, TAS]

eukaryotic translation elongation factor 1 complex [TAS]

extracellular space [IDA]

extracellular vesicular exosome [IDA]

nucleolus [IDA]

CRISPR Database HGNC Alliance of Genome Resources OMIM Entrez Gene RefSeq UniprotKB Ensembl HPRD

Homo sapiens

Two-hybrid

Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.

Publication

A yeast two-hybrid screen reveals that osteopontin associates with MAP1A and MAP1B in addition to other proteins linked to microtubule stability, apoptosis and protein degradation in the human brain.

Long P, Samnakay P, Jenner P, Rose S

Osteopontin (OPN) expression is reduced in surviving dopaminergic neurones in the substantia nigra (SN) in Parkinson's disease (PD), and protects against MPP(+) -induced cell death in primary mesencephalic cultures and 6-OHDA-induced cell loss in the rat, while inactivation of OPN aggravates cell death. OPN is thought to act through interactions with integrin receptors or CD44. However, the specific protein interactions ... [more]

Unknown Jul. 11, 2012; 0(0); [Pubmed: 22779921]

Throughput

Low Throughput

Curated By

BioGRID