BAIT

SPP1

BNSP, BSPI, ETA-1, OPN, PSEC0156
secreted phosphoprotein 1
GO Process (5)
GO Function (1)
GO Component (3)
Homo sapiens

Two-hybrid

Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.

Publication

A yeast two-hybrid screen reveals that osteopontin associates with MAP1A and MAP1B in addition to other proteins linked to microtubule stability, apoptosis and protein degradation in the human brain.

Long P, Samnakay P, Jenner P, Rose S

Osteopontin (OPN) expression is reduced in surviving dopaminergic neurones in the substantia nigra (SN) in Parkinson's disease (PD), and protects against MPP(+) -induced cell death in primary mesencephalic cultures and 6-OHDA-induced cell loss in the rat, while inactivation of OPN aggravates cell death. OPN is thought to act through interactions with integrin receptors or CD44. However, the specific protein interactions ... [more]

Unknown Jul. 11, 2012; 0(0); [Pubmed: 22779921]

Throughput

  • Low Throughput

Curated By

  • BioGRID