BAIT
SPP1
BNSP, BSPI, ETA-1, OPN, PSEC0156
secreted phosphoprotein 1
GO Process (5)
GO Function (1)
GO Component (3)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
RAPGEF2
CNrasGEF, NRAPGEP, PDZ-GEF1, PDZGEF1, RA-GEF, RA-GEF-1, Rap-GEP, nRap GEP
Rap guanine nucleotide exchange factor (GEF) 2
GO Process (35)
GO Function (12)
GO Component (11)
Gene Ontology Biological Process
- G-protein coupled receptor signaling pathway [IDA]
- MAPK cascade [NAS]
- Rap protein signal transduction [IMP]
- adenylate cyclase-activating adrenergic receptor signaling pathway [IDA]
- blood vessel development [ISS]
- brain-derived neurotrophic factor receptor signaling pathway [ISS]
- cAMP-mediated signaling [IDA, NAS]
- cellular response to cAMP [IDA]
- cellular response to cGMP [IDA]
- cellular response to nerve growth factor stimulus [ISS]
- establishment of endothelial barrier [IMP]
- forebrain neuron development [ISS]
- intracellular signal transduction [TAS]
- negative regulation of cell proliferation [IDA]
- negative regulation of dendrite morphogenesis [IDA]
- negative regulation of melanin biosynthetic process [ISS]
- nerve growth factor signaling pathway [ISS]
- neuron migration [ISS]
- neuron projection development [IDA]
- neuropeptide signaling pathway [IDA]
- positive regulation of ERK1 and ERK2 cascade [IDA]
- positive regulation of Rap GTPase activity [IDA, IMP]
- positive regulation of Ras GTPase activity [IDA]
- positive regulation of cAMP-dependent protein kinase activity [IDA]
- positive regulation of cAMP-mediated signaling [IDA]
- positive regulation of dendritic cell apoptotic process [IDA]
- positive regulation of neuron migration [ISS]
- positive regulation of neuron projection development [ISS]
- positive regulation of protein binding [ISS]
- positive regulation of protein kinase activity [IDA]
- positive regulation of vasculogenesis [ISS]
- regulation of cell junction assembly [IMP]
- regulation of synaptic plasticity [ISS]
- small GTPase mediated signal transduction [TAS]
- ventricular system development [ISS]
Gene Ontology Molecular Function- PDZ domain binding [IDA]
- Rap GTPase activator activity [IDA]
- Rap guanyl-nucleotide exchange factor activity [IDA, IMP]
- Ras guanyl-nucleotide exchange factor activity [IDA]
- WW domain binding [IDA]
- beta-1 adrenergic receptor binding [IDA]
- cAMP binding [IDA]
- cGMP binding [IDA]
- calcium ion binding [NAS]
- diacylglycerol binding [NAS]
- protein binding [IPI]
- signal transducer activity [TAS]
- PDZ domain binding [IDA]
- Rap GTPase activator activity [IDA]
- Rap guanyl-nucleotide exchange factor activity [IDA, IMP]
- Ras guanyl-nucleotide exchange factor activity [IDA]
- WW domain binding [IDA]
- beta-1 adrenergic receptor binding [IDA]
- cAMP binding [IDA]
- cGMP binding [IDA]
- calcium ion binding [NAS]
- diacylglycerol binding [NAS]
- protein binding [IPI]
- signal transducer activity [TAS]
Gene Ontology Cellular Component
Homo sapiens
Two-hybrid
Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.
Publication
A yeast two-hybrid screen reveals that osteopontin associates with MAP1A and MAP1B in addition to other proteins linked to microtubule stability, apoptosis and protein degradation in the human brain.
Osteopontin (OPN) expression is reduced in surviving dopaminergic neurones in the substantia nigra (SN) in Parkinson's disease (PD), and protects against MPP(+) -induced cell death in primary mesencephalic cultures and 6-OHDA-induced cell loss in the rat, while inactivation of OPN aggravates cell death. OPN is thought to act through interactions with integrin receptors or CD44. However, the specific protein interactions ... [more]
Unknown Jul. 11, 2012; 0(0); [Pubmed: 22779921]
Throughput
- Low Throughput
Curated By
- BioGRID