PINK1
Gene Ontology Biological Process
- TORC2 signaling [IC]
- activation of protein kinase B activity [IC]
- cellular response to hypoxia [IMP]
- cellular response to toxic substance [TAS]
- intracellular signal transduction [IDA]
- mitochondrion degradation [IMP]
- mitochondrion organization [IMP]
- negative regulation of JNK cascade [TAS]
- negative regulation of gene expression [ISS]
- negative regulation of hydrogen peroxide-induced neuron intrinsic apoptotic signaling pathway [IDA, IMP]
- negative regulation of neuron apoptotic process [IMP]
- negative regulation of oxidative stress-induced cell death [IDA]
- negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway [IDA]
- negative regulation of oxidative stress-induced neuron death [TAS]
- negative regulation of reactive oxygen species metabolic process [IMP]
- peptidyl-serine autophosphorylation [TAS]
- peptidyl-serine phosphorylation [IDA, TAS]
- phosphorylation [NAS]
- positive regulation of I-kappaB kinase/NF-kappaB signaling [IDA]
- positive regulation of mitochondrial electron transport, NADH to ubiquinone [TAS]
- positive regulation of mitochondrial fission [IBA]
- positive regulation of peptidase activity [TAS]
- positive regulation of peptidyl-serine phosphorylation [IDA, TAS]
- positive regulation of protein kinase B signaling [IC]
- positive regulation of release of cytochrome c from mitochondria [IMP]
- positive regulation of ubiquitin-protein transferase activity [TAS]
- protein phosphorylation [IDA, TAS]
- protein ubiquitination [IMP]
- regulation of mitochondrial membrane potential [IGI, IMP]
- regulation of mitochondrion degradation [TAS]
- regulation of protein complex assembly [IDA]
- regulation of protein ubiquitination [IDA]
- regulation of reactive oxygen species metabolic process [IGI, IMP]
- regulation of synaptic vesicle transport [TAS]
- response to oxidative stress [IGI]
- response to stress [IDA]
- ubiquitin-dependent protein catabolic process [TAS]
Gene Ontology Molecular Function- ATP binding [IDA]
- C3HC4-type RING finger domain binding [IPI]
- calcium-dependent protein kinase activity [IDA]
- kinase activity [IDA, NAS]
- magnesium ion binding [IDA]
- peptidase activator activity [TAS]
- protease binding [IPI, TAS]
- protein binding [IPI]
- protein kinase B binding [IDA]
- protein serine/threonine kinase activity [IDA, TAS]
- ubiquitin protein ligase binding [IPI]
- ATP binding [IDA]
- C3HC4-type RING finger domain binding [IPI]
- calcium-dependent protein kinase activity [IDA]
- kinase activity [IDA, NAS]
- magnesium ion binding [IDA]
- peptidase activator activity [TAS]
- protease binding [IPI, TAS]
- protein binding [IPI]
- protein kinase B binding [IDA]
- protein serine/threonine kinase activity [IDA, TAS]
- ubiquitin protein ligase binding [IPI]
Gene Ontology Cellular Component
- Lewy body [TAS]
- TORC2 complex [IPI]
- astrocyte projection [IDA]
- axon [IDA]
- cell body [IDA]
- chromatin [IDA]
- cytoplasm [IDA]
- cytoskeleton [IDA]
- cytosol [IDA]
- integral component of mitochondrial outer membrane [IDA]
- membrane [IDA]
- mitochondrial inner membrane [IDA]
- mitochondrial intermembrane space [IDA]
- mitochondrial outer membrane [IDA]
- mitochondrion [IDA]
- nucleus [IDA]
- perinuclear region of cytoplasm [IDA]
PSMD1
Gene Ontology Biological Process
- DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest [TAS]
- G1/S transition of mitotic cell cycle [TAS]
- RNA metabolic process [TAS]
- anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process [TAS]
- antigen processing and presentation of exogenous peptide antigen via MHC class I [TAS]
- antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent [TAS]
- antigen processing and presentation of peptide antigen via MHC class I [TAS]
- apoptotic process [TAS]
- cellular nitrogen compound metabolic process [TAS]
- gene expression [TAS]
- mRNA metabolic process [TAS]
- mitotic cell cycle [TAS]
- negative regulation of apoptotic process [TAS]
- negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle [TAS]
- positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle [TAS]
- protein polyubiquitination [TAS]
- regulation of apoptotic process [TAS]
- regulation of cellular amino acid metabolic process [TAS]
- regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle [TAS]
- small molecule metabolic process [TAS]
- viral process [TAS]
Gene Ontology Cellular Component
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
The loss of PGAM5 suppresses the mitochondrial degeneration caused by inactivation of PINK1 in Drosophila.
PTEN-induced kinase 1 (PINK1), which is required for mitochondrial homeostasis, is a gene product responsible for early-onset Parkinson's disease (PD). Another early onset PD gene product, Parkin, has been suggested to function downstream of the PINK1 signalling pathway based on genetic studies in Drosophila. PINK1 is a serine/threonine kinase with a predicted mitochondrial target sequence and a probable transmembrane domain ... [more]
Throughput
- High Throughput
Ontology Terms
- hek-293 cell (BTO:0000007)
Additional Notes
- exogenous expression of bait
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| PINK1 PSMD1 | Affinity Capture-Western Affinity Capture-Western An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins. | Low | - | BioGRID | - | |
| PSMD1 PINK1 | Affinity Capture-Western Affinity Capture-Western An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins. | Low | - | BioGRID | - |
Curated By
- BioGRID