MTOR
Gene Ontology Biological Process
- TOR signaling [ISO]
- cell growth [ISO]
- cell projection organization [IMP, ISO]
- cellular response to hypoxia [IDA]
- cellular response to nutrient levels [IDA]
- double-strand break repair via homologous recombination [IBA]
- germ cell development [IDA]
- negative regulation of NFAT protein import into nucleus [IMP]
- negative regulation of autophagy [IMP]
- negative regulation of cell size [IGI, ISO]
- negative regulation of macroautophagy [IMP]
- peptidyl-serine phosphorylation [IMP, ISO]
- peptidyl-threonine phosphorylation [IDA]
- phosphorylation [ISO]
- positive regulation of actin filament polymerization [IDA, IMP]
- positive regulation of endothelial cell proliferation [ISO]
- positive regulation of gene expression [ISO]
- positive regulation of lamellipodium assembly [IDA]
- positive regulation of lipid biosynthetic process [ISO]
- positive regulation of myotube differentiation [IGI]
- positive regulation of peptidyl-tyrosine phosphorylation [IMP]
- positive regulation of protein kinase B signaling [ISO]
- positive regulation of protein phosphorylation [ISO]
- positive regulation of stress fiber assembly [IDA]
- positive regulation of transcription from RNA polymerase III promoter [ISO]
- positive regulation of translation [ISO]
- protein autophosphorylation [ISO]
- protein phosphorylation [ISO]
- regulation of Rac GTPase activity [IMP]
- regulation of actin cytoskeleton organization [ISO]
- regulation of carbohydrate metabolic process [ISO]
- regulation of carbohydrate utilization [ISO]
- regulation of fatty acid beta-oxidation [ISO]
- regulation of glycogen biosynthetic process [ISO]
- regulation of myelination [IMP]
- regulation of protein kinase activity [IGI]
- regulation of response to food [ISO]
- response to amino acid [IDA, ISO]
- response to insulin [IDA]
- response to stress [ISO]
- ruffle organization [IDA]
Gene Ontology Molecular Function- RNA polymerase III type 1 promoter DNA binding [ISO]
- RNA polymerase III type 2 promoter DNA binding [ISO]
- RNA polymerase III type 3 promoter DNA binding [ISO]
- TFIIIC-class transcription factor binding [ISO]
- kinase activity [ISO]
- phosphoprotein binding [ISO]
- protein binding [IPI]
- protein dimerization activity [IBA]
- protein domain specific binding [ISO]
- protein serine/threonine kinase activity [IDA, ISO]
- ribosome binding [IDA]
- RNA polymerase III type 1 promoter DNA binding [ISO]
- RNA polymerase III type 2 promoter DNA binding [ISO]
- RNA polymerase III type 3 promoter DNA binding [ISO]
- TFIIIC-class transcription factor binding [ISO]
- kinase activity [ISO]
- phosphoprotein binding [ISO]
- protein binding [IPI]
- protein dimerization activity [IBA]
- protein domain specific binding [ISO]
- protein serine/threonine kinase activity [IDA, ISO]
- ribosome binding [IDA]
Gene Ontology Cellular Component
RICTOR
Gene Ontology Biological Process
- Fc-epsilon receptor signaling pathway [TAS]
- T cell costimulation [TAS]
- actin cytoskeleton reorganization [IMP]
- embryo development [ISS]
- epidermal growth factor receptor signaling pathway [TAS]
- fibroblast growth factor receptor signaling pathway [TAS]
- innate immune response [TAS]
- neurotrophin TRK receptor signaling pathway [TAS]
- peptidyl-serine phosphorylation [IGI]
- phosphatidylinositol-mediated signaling [TAS]
- positive regulation of TOR signaling [IMP]
- regulation of actin cytoskeleton organization [IMP]
- regulation of protein kinase B signaling [IDA]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
mTORC1 signaling requires proteasomal function and the involvement of CUL4-DDB1 ubiquitin E3 ligase.
The mammalian target-of-rapamycin (mTOR) signaling pathway serves as a major regulator of cell growth, cell size and metabolism. In vivo, mTOR exists in two complexes, both of which contain the catalytic subunit mTOR, the invariable subunit mLST8, and a complex specific subunit Raptor or Rictor, forming either the rapamycin-sensitive mTORC1 or rapamycin-insensitive mTORC2, respectively. The exact functions of Raptor or ... [more]
Throughput
- Low Throughput
Curated By
- BioGRID