BAIT
TERF1
PIN2, TRBF1, TRF, TRF1, hTRF1-AS, t-TRF1
telomeric repeat binding factor (NIMA-interacting) 1
GO Process (15)
GO Function (8)
GO Component (7)
Gene Ontology Biological Process
- G2/M transition of mitotic cell cycle [IEP]
- age-dependent telomere shortening [IDA]
- mitotic spindle assembly checkpoint [IMP]
- negative regulation of DNA replication [IDA]
- negative regulation of telomerase activity [IGI]
- negative regulation of telomere maintenance via semi-conservative replication [NAS]
- negative regulation of telomere maintenance via telomerase [IGI]
- positive regulation of apoptotic process [IDA]
- positive regulation of microtubule polymerization [IDA]
- positive regulation of mitosis [IMP]
- positive regulation of mitotic cell cycle [IMP]
- protein homooligomerization [IDA]
- telomere maintenance [TAS]
- telomere maintenance via telomerase [IMP, NAS]
- telomeric loop formation [IBA]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
AKR1A1
ALDR1, ALR, ARM, DD3, HEL-S-6, RP4-697E16.2
aldo-keto reductase family 1, member A1 (aldehyde reductase)
GO Process (2)
GO Function (2)
GO Component (2)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Two-hybrid
Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.
Publication
Genome-wide YFP fluorescence complementation screen identifies new regulators for telomere signaling in human cells.
Detection of low-affinity or transient interactions can be a bottleneck in our understanding of signaling networks. To address this problem, we developed an arrayed screening strategy based on protein complementation to systematically investigate protein-protein interactions in live human cells, and performed a large-scale screen for regulators of telomeres. Maintenance of vertebrate telomeres requires the concerted action of members of the ... [more]
Mol. Cell Proteomics Feb. 01, 2011; 10(2);M110.001628 [Pubmed: 21044950]
Throughput
- High Throughput
Additional Notes
- BifC
Curated By
- BioGRID